biostudies-literatureWu BScience and Technology Planning Project of Jiangmen, Chinae0240230https://www.ebi.ac.uk/biostudies/studies/S-EPMC7595405biostudies-literatureUnknown15(10)<h4>Objective</h4>Our study is to identify DEGs (Differentially Expressed Genes), comprehensively investigate hub genes, annotate enrichment functions and key pathways of Non-functional pituitary adenomas (NFPAs), and also to verify STO-609 therapeutic effect.<h4>Methods</h4>The gene expression level of NFPA and normal tissues were compared to identify the DEGs (Differential expressed genes) based on gene expression profiles (GSE2175, GSE26966 and GSE51618). Enrichment functions, pathways and key genes were identified by carrying out GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis and PPI (Protein-Protein Interation) network analysis. Moreover, experiments in vitro were conducted to verify the anti-NFPAs effects of STO-609.<h4>Results</h4>169 over-expression genPloS oneIdentification of driver genes and key pathways of non-functional pituitary adenomas predicts the therapeutic effect of STO-609.PMC75954052018630100110019805Hu FDou GZhong SDong JWu BJiang SChen YWang XYi DWu YBi YLiu GfalseIdentification of driver genes and key pathways of non-functional pituitary adenomas predicts the therapeutic effect of STO-609.<h4>Objective</h4>Our study is to identify DEGs (Differentially Expressed Genes), comprehensively investigate hub genes, annotate enrichment functions and key pathways of Non-functional pituitary adenomas (NFPAs), and also to verify STO-609 therapeutic effect.<h4>Methods</h4>The gene expression level of NFPA and normal tissues were compared to identify the DEGs (Differential expressed genes) based on gene expression profiles (GSE2175, GSE26966 and GSE51618). Enrichment functions, pathways and key genes were identified by carrying out GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis and PPI (Protein-Protein Interation) network analysis. Moreover, experiments in vitro were conducted to verify the anti-NFPAs effects of STO-609.<h4>Results</h4>169 over-expression gen2020-01-01T00:00:00Z20202026-05-01T01:32:17.498Z2020-11-08T09:44:36ZS-EPMC75954053311959710.1371/journal.pone.0240230