{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Warner ET"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","NCRR NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","National Cancer Institute","NCI NIH HHS","National Institutes of Health","John Templeton Foundation"],"pagination":["e0241363"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7598522"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(10)"],"pubmed_abstract":["<h4>Introduction</h4>We examined whether abuse in childhood and/or adolescence was associated with shorter telomere length in a pooled analysis of 3,232 participants from five diverse cohorts. We also assessed whether religion or spirituality (R/S) could buffer deleterious effects of abuse.<h4>Methods</h4>Physical and sexual abuse in childhood (age <12) and adolescence (age 12-18) was assessed using the Revised Conflict Tactics Scale and questions from a 1995 Gallup survey. We measured relative leukocyte telomere lengths (RTL) using quantitative real time polymerase chain reaction. We used generalized estimating equations to assess associations of physical and sexual abuse with log-transformed RTL z-scores. Analyses were conducted in each cohort, overall, and stratified by extent of religiosity or spirituality and religious coping in adulthood. We pooled study-specific estimates using random-effects models and assessed between-study heterogeneity.<h4>Results</h4>Compared to no abuse, severe sexual abuse was associated with lower RTL z-scores, in childhood: -15.6%, 95% CI: -25.9, -4.9; p-trend = 0.04; p-heterogeneity = 0.58 and in adolescence: -16.5%, 95% CI: -28.1, -3.0; p-trend = 0.08; p-heterogeneity = 0.68. Sexual abuse experienced in both childhood and adolescence was associated with 11.3% lower RTL z-scores after adjustment for childhood and demographic covariates (95% CI: -20.5%, -2.0%; p-trend = 0.03; p-heterogeneity = 0.62). There was no evidence of effect modification by R/S. Physical abuse was not associated with telomere length.<h4>Conclusions</h4>Sexual abuse in childhood or adolescence was associated with a marker of accelerated biological aging, decreased telomere length. The lack of moderation by R/S may be due to inability to capture the appropriate time period for those beliefs and practices."],"journal":["PloS one"],"pubmed_title":["Physical and sexual abuse in childhood and adolescence and leukocyte telomere length: A pooled analysis of the study on psychosocial stress, spirituality, and health."],"pmcid":["PMC7598522"],"funding_grant_id":["75N92019D00028","75N92019D00027","R01CA058420","75N92019D00029","R01 HL109301","U01 CA176726","U01HL41642","R01 HL109284","R01 HL109282","R01CA67262","U01 HL065520","U01 HL041652","U01 HL065521","R01HL109319","U01 HL041654","K01 CA188075","R01 HL093009","75N92019D00030","R01 CA163451","R01 HL120725","U01CA164974","R01CA098663","59607","UL1 RR024131","R01HL109315","UL1RR024131","R01 HL109315","R01HL109284","R01 CA098663","R01CA163451","U01 CA164974","R01HL109282","UL1 TR001872","K24 HL112827","UL1TR001872","K01CA188075","U01HL65521","U01HL41652","U01HL65520","U01HL41654","R01 CA067262","P30 DK098722","U01CA176726","U01 HL041642","R01HL093009","R01HL109301","R01 CA058420","R01 HL109319"],"pubmed_authors":["Cole SA","Gu Y","Pereira A","Tworoger S","Cozier Y","Warner ET","Kandula NR","Palmer JR","Spence ND","DeVivo I","Zhang Y","Shields A","Kanaya AM","Taporoski TP"],"additional_accession":[]},"is_claimable":false,"name":"Physical and sexual abuse in childhood and adolescence and leukocyte telomere length: A pooled analysis of the study on psychosocial stress, spirituality, and health.","description":"<h4>Introduction</h4>We examined whether abuse in childhood and/or adolescence was associated with shorter telomere length in a pooled analysis of 3,232 participants from five diverse cohorts. We also assessed whether religion or spirituality (R/S) could buffer deleterious effects of abuse.<h4>Methods</h4>Physical and sexual abuse in childhood (age <12) and adolescence (age 12-18) was assessed using the Revised Conflict Tactics Scale and questions from a 1995 Gallup survey. We measured relative leukocyte telomere lengths (RTL) using quantitative real time polymerase chain reaction. We used generalized estimating equations to assess associations of physical and sexual abuse with log-transformed RTL z-scores. Analyses were conducted in each cohort, overall, and stratified by extent of religiosity or spirituality and religious coping in adulthood. We pooled study-specific estimates using random-effects models and assessed between-study heterogeneity.<h4>Results</h4>Compared to no abuse, severe sexual abuse was associated with lower RTL z-scores, in childhood: -15.6%, 95% CI: -25.9, -4.9; p-trend = 0.04; p-heterogeneity = 0.58 and in adolescence: -16.5%, 95% CI: -28.1, -3.0; p-trend = 0.08; p-heterogeneity = 0.68. Sexual abuse experienced in both childhood and adolescence was associated with 11.3% lower RTL z-scores after adjustment for childhood and demographic covariates (95% CI: -20.5%, -2.0%; p-trend = 0.03; p-heterogeneity = 0.62). There was no evidence of effect modification by R/S. Physical abuse was not associated with telomere length.<h4>Conclusions</h4>Sexual abuse in childhood or adolescence was associated with a marker of accelerated biological aging, decreased telomere length. The lack of moderation by R/S may be due to inability to capture the appropriate time period for those beliefs and practices.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2024-11-19T15:45:32.793Z","creation":"2020-11-08T09:45:33Z"},"accession":"S-EPMC7598522","cross_references":{"pubmed":["33125425"],"doi":["10.1371/journal.pone.0241363"]}}