{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ku J"],"funding":["Ministry of Science, ICT and Future Planning","This research was also supported with the computing resources by Global Science experimental Data hub Center (GSDC) & Korea Research Environment Open NETwork (KREONET)."],"pagination":["630"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7599330"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(1)"],"pubmed_abstract":["Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a non-enzymatic component required for the multi-tRNA synthetase complex. While exon 2 skipping alternatively spliced variant of AIMP2 (AIMP2-DX2) compromises AIMP2 activity and is associated with carcinogenesis, its clinical potential awaits further validation. Here, we found that AIMP2-DX2/AIMP2 expression ratio is strongly correlated with major cancer signaling pathways and poor prognosis, particularly in acute myeloid leukemia (AML). Analysis of a clinical patient cohort revealed that AIMP2-DX2 positive AML patients show decreased overall survival and progression-free survival. We also developed targeted RNA-sequencing and single-molecule RNA-FISH tools to quantitatively analyze AIMP2-DX2/AIMP2 ratios at the sin"],"journal":["Communications biology"],"pubmed_title":["Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer."],"pmcid":["PMC7599330"],"funding_grant_id":["NRF-2014M3A6A4074727","NRF-2019R1C1C1006672"],"pubmed_authors":["Kim S","Kim D","Kim R","Lee N","Ku J","Yoon SS","Song S","Lee K","Koh Y","Kim Y","Kwon NH","Kim M"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer.","description":"Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a non-enzymatic component required for the multi-tRNA synthetase complex. While exon 2 skipping alternatively spliced variant of AIMP2 (AIMP2-DX2) compromises AIMP2 activity and is associated with carcinogenesis, its clinical potential awaits further validation. Here, we found that AIMP2-DX2/AIMP2 expression ratio is strongly correlated with major cancer signaling pathways and poor prognosis, particularly in acute myeloid leukemia (AML). Analysis of a clinical patient cohort revealed that AIMP2-DX2 positive AML patients show decreased overall survival and progression-free survival. We also developed targeted RNA-sequencing and single-molecule RNA-FISH tools to quantitatively analyze AIMP2-DX2/AIMP2 ratios at the sin","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-06-01T03:53:32.805Z","creation":"2025-06-01T03:53:32.805Z"},"accession":"S-EPMC7599330","cross_references":{"pubmed":["33128014"],"doi":["10.1038/s42003-020-01353-x"]}}