{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martijn J"],"funding":["Vetenskapsrådet","European Research Council","Dutch Research Council (NWO)"],"pagination":["5490"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7599335"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Halobacteria (henceforth: Haloarchaea) are predominantly aerobic halophiles that are thought to have evolved from anaerobic methanogens. This remarkable transformation most likely involved an extensive influx of bacterial genes. Whether it entailed a single massive transfer event or a gradual stream of transfers remains a matter of debate. To address this, genomes that descend from methanogen-to-halophile intermediates are necessary. Here, we present five such near-complete genomes of Marine Group IV archaea (Hikarchaeia), the closest known relatives of Haloarchaea. Their inclusion in gene tree-aware ancestral reconstructions reveals an intermediate stage that had already lost a large number of genes, including nearly all of those involved in methanogenesis and the Wood-Ljungdahl pathway. "],"journal":["Nature communications"],"pubmed_title":["Hikarchaeia demonstrate an intermediate stage in the methanogen-to-halophile transition."],"pmcid":["PMC7599335"],"funding_grant_id":["817834","2016-03559","310039","2018-06727","WISE fellowship"],"pubmed_authors":["Schon ME","Spang A","Williams TA","Lind AE","Ettema TJG","Martijn J","Vosseberg J"],"additional_accession":[]},"is_claimable":false,"name":"Hikarchaeia demonstrate an intermediate stage in the methanogen-to-halophile transition.","description":"Halobacteria (henceforth: Haloarchaea) are predominantly aerobic halophiles that are thought to have evolved from anaerobic methanogens. This remarkable transformation most likely involved an extensive influx of bacterial genes. Whether it entailed a single massive transfer event or a gradual stream of transfers remains a matter of debate. To address this, genomes that descend from methanogen-to-halophile intermediates are necessary. Here, we present five such near-complete genomes of Marine Group IV archaea (Hikarchaeia), the closest known relatives of Haloarchaea. Their inclusion in gene tree-aware ancestral reconstructions reveals an intermediate stage that had already lost a large number of genes, including nearly all of those involved in methanogenesis and the Wood-Ljungdahl pathway. ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-26T16:48:44.619Z","creation":"2020-11-19T11:32:13Z"},"accession":"S-EPMC7599335","cross_references":{"pubmed":["33127909"],"doi":["10.1038/s41467-020-19200-2"]}}