{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schub D"],"funding":["Dr. Rolf M. Schwiete Stiftung","Universität des Saarlandes","State of Saarland"],"pagination":["142167"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7605520"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(20)"],"pubmed_abstract":["BACKGROUNDPatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) differ in the severity of disease. We hypothesized that characteristics of SARS-CoV-2-specific immunity correlate with disease severity.METHODSIn this study, SARS-CoV-2-specific T cells and antibodies were characterized in uninfected controls and patients with different coronavirus disease 2019 (COVID-19) disease severity. SARS-CoV-2-specific T cells were flow cytometrically quantified after stimulation with SARS-CoV-2 peptide pools and analyzed for expression of cytokines (IFN-γ, IL-2, and TNF-α) and markers for activation, proliferation, and functional anergy. SARS-CoV-2-specific IgG and IgA antibodies were quantified using ELISA. Moreover, global characteristics of lymphocyte subpopulations wer"],"journal":["JCI insight"],"pubmed_title":["High levels of SARS-CoV-2-specific T cells with restricted functionality in severe courses of COVID-19."],"pmcid":["PMC7605520"],"funding_grant_id":["no number"],"pubmed_authors":["Sester M","Schub D","Klemis V","Bals R","Schneitler S","Sester U","Lepper PM","Mihm J","Wilkens H","Eichler H","Schmidt T","Gartner BC","Becker SL"],"additional_accession":[]},"is_claimable":false,"name":"High levels of SARS-CoV-2-specific T cells with restricted functionality in severe courses of COVID-19.","description":"BACKGROUNDPatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) differ in the severity of disease. We hypothesized that characteristics of SARS-CoV-2-specific immunity correlate with disease severity.METHODSIn this study, SARS-CoV-2-specific T cells and antibodies were characterized in uninfected controls and patients with different coronavirus disease 2019 (COVID-19) disease severity. SARS-CoV-2-specific T cells were flow cytometrically quantified after stimulation with SARS-CoV-2 peptide pools and analyzed for expression of cytokines (IFN-γ, IL-2, and TNF-α) and markers for activation, proliferation, and functional anergy. SARS-CoV-2-specific IgG and IgA antibodies were quantified using ELISA. Moreover, global characteristics of lymphocyte subpopulations wer","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-06-01T03:53:20.838Z","creation":"2025-06-01T03:53:20.838Z"},"accession":"S-EPMC7605520","cross_references":{"pubmed":["32937615"],"doi":["10.1172/jci.insight.142167"]}}