{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(19)"],"submitter":["Spence JD"],"pubmed_abstract":["Patients with asymptomatic carotid stenosis (ACS) are at very high risk of coronary events, so they should all receive intensive medical therapy. What is often accepted as \"best medical therapy\" is usually suboptimal. Truly intensive medical therapy includes lifestyle modification, particularly smoking cessation and a Mediterranean diet. All patients with ACS should receive intensive lipid-lowering therapy, should have their blood pressure well controlled, and should receive B vitamins for lowering of plasma total homocysteine (tHcy) if levels are high; a commonly missed cause of elevated tHcy is metabolic B12 deficiency, which should be diagnosed and treated. Most patients with ACS would be better treated with intensive medical therapy than with either carotid endarterectomy (CEA) or sten"],"journal":["Annals of translational medicine"],"pagination":["1262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7607083"],"repository":["biostudies-literature"],"pubmed_title":["Management of asymptomatic carotid stenosis."],"pmcid":["PMC7607083"],"pubmed_authors":["Spence JD"],"additional_accession":[]},"is_claimable":false,"name":"Management of asymptomatic carotid stenosis.","description":"Patients with asymptomatic carotid stenosis (ACS) are at very high risk of coronary events, so they should all receive intensive medical therapy. What is often accepted as \"best medical therapy\" is usually suboptimal. Truly intensive medical therapy includes lifestyle modification, particularly smoking cessation and a Mediterranean diet. All patients with ACS should receive intensive lipid-lowering therapy, should have their blood pressure well controlled, and should receive B vitamins for lowering of plasma total homocysteine (tHcy) if levels are high; a commonly missed cause of elevated tHcy is metabolic B12 deficiency, which should be diagnosed and treated. Most patients with ACS would be better treated with intensive medical therapy than with either carotid endarterectomy (CEA) or sten","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-19T23:39:49.411Z","creation":"2025-04-19T23:39:49.411Z"},"accession":"S-EPMC7607083","cross_references":{"pubmed":["33178794"],"doi":["10.21037/atm-20-975"]}}