biostudies-literatureUnknown8(19)Wang Z<h4>Background</h4>Thyrotropin (TSH) suppression is a critical step in the management of differentiated thyroid carcinoma (DTC). The objectives of this study were to evaluate changes in TSH levels and a strategy of initial levothyroxine (LT4) supplementation for TSH suppression in low-risk differentiated thyroid carcinoma (lr-DTC) patients after lobectomy.<h4>Methods</h4>One hundred and ten patients with lr-DTC who received lobectomy were enrolled. Each of the patients was given 50 µg LT4 immediately after lobectomy and were retrospectively analyzed to evaluate the initial dose of LT4 suppression during the first year of follow-up. Risk factors influencing the TSH trend were also evaluated.<h4>Results</h4>Median TSH levels decreased significantly after lobectomy and the initiation of LT4 sAnnals of translational medicine1238https://www.ebi.ac.uk/biostudies/studies/S-EPMC7607107biostudies-literatureAnalysis of the strategy of LT4 prescribing and TSH monitoring for thyroid carcinoma after lobectomy.PMC7607107Dong WZhang DGuan HAngell TEShao LZhang HQin YLv CSun WHe LZhang PZhang TWang ZfalseAnalysis of the strategy of LT4 prescribing and TSH monitoring for thyroid carcinoma after lobectomy.<h4>Background</h4>Thyrotropin (TSH) suppression is a critical step in the management of differentiated thyroid carcinoma (DTC). The objectives of this study were to evaluate changes in TSH levels and a strategy of initial levothyroxine (LT4) supplementation for TSH suppression in low-risk differentiated thyroid carcinoma (lr-DTC) patients after lobectomy.<h4>Methods</h4>One hundred and ten patients with lr-DTC who received lobectomy were enrolled. Each of the patients was given 50 µg LT4 immediately after lobectomy and were retrospectively analyzed to evaluate the initial dose of LT4 suppression during the first year of follow-up. Risk factors influencing the TSH trend were also evaluated.<h4>Results</h4>Median TSH levels decreased significantly after lobectomy and the initiation of LT4 s2020-01-01T00:00:00Z2020 Oct2025-04-04T23:46:38.287Z2024-10-17T23:36:33.095ZS-EPMC76071073317877010.21037/atm-20-4890