{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(19)"],"submitter":["Fernandes E Fernandes J"],"pubmed_abstract":["Management of asymptomatic carotid disease continues to challenge medical practice and present evidence is often conflicting. Stroke is a significant burden in Public Health and 11% to 15% appear as first neurologic event associated with asymptomatic carotid stenosis. Randomized trials provided support for Guidelines and Recommendations to intervene on asymptomatic stenosis, but at a known cost of a high number of unnecessary operations. Conflicting evidence from natural history studies and the widespread use of proper medical management including risk factors control, lowering-lipid drugs and strict control of arterial hypertension have reduced the incidence of strokes associated to asymptomatic carotid disease challenging established practice. Need to identify vulnerable lesions prone to"],"journal":["Annals of translational medicine"],"pagination":["1279"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7607137"],"repository":["biostudies-literature"],"pubmed_title":["The conundrum of asymptomatic carotid stenosis-determinants of decision and evidence."],"pmcid":["PMC7607137"],"pubmed_authors":["Goncalves I","Mendes Pedro L","Fernandes E Fernandes J"],"additional_accession":[]},"is_claimable":false,"name":"The conundrum of asymptomatic carotid stenosis-determinants of decision and evidence.","description":"Management of asymptomatic carotid disease continues to challenge medical practice and present evidence is often conflicting. Stroke is a significant burden in Public Health and 11% to 15% appear as first neurologic event associated with asymptomatic carotid stenosis. Randomized trials provided support for Guidelines and Recommendations to intervene on asymptomatic stenosis, but at a known cost of a high number of unnecessary operations. Conflicting evidence from natural history studies and the widespread use of proper medical management including risk factors control, lowering-lipid drugs and strict control of arterial hypertension have reduced the incidence of strokes associated to asymptomatic carotid disease challenging established practice. Need to identify vulnerable lesions prone to","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-26T20:49:18.861Z","creation":"2025-04-06T16:32:38.37Z"},"accession":"S-EPMC7607137","cross_references":{"pubmed":["33178811"],"doi":["10.21037/atm-2020-cass-12"]}}