biostudies-literatureUnknown2020Herrera-Calderon OUniversidad Nacional Mayor de San MarcosCarvacrol is a phenol monoterpene found in aromatic plants specially in Lamiaceae family, which has been evaluated in an experimental model of breast cancer. However, any proposed mechanism based on its antitumor effect has not been reported. In our previous study, carvacrol showed a protective effect on 7,12-dimethylbenz[α]anthracene- (DMBA-) induced breast cancer in female rats. The main objective in this research was to evaluate by using in silico study the carvacrol on HER2, PI3Kα, mTOR, hER-α, PR, and EGFR receptors involved in breast cancer progression by docking analysis, molecular dynamic, and drug-likeness evaluation. A multilevel computational study to evaluate the antitumor potential of carvacrol focusing on the main targets involved in the breast canEvidence-based complementary and alternative medicine : eCAM8830665https://www.ebi.ac.uk/biostudies/studies/S-EPMC7607278biostudies-literatureCarvacrol: An In Silico Approach of a Candidate Drug on HER2, PI3Kα, mTOR, hER-α, PR, and EGFR Receptors in the Breast Cancer.PMC7607278Arroyo-Acevedo JLQuintero-Saumeth JRojas-Armas JPAndia-Ayme VYepes-Perez AFFigueroa-Salvador LPalomino-Pacheco MCieza-Macedo ECHerrera-Calderon OOrtiz-Sanchez JMPena-Rojas GfalseCarvacrol: An In Silico Approach of a Candidate Drug on HER2, PI3Kα, mTOR, hER-α, PR, and EGFR Receptors in the Breast Cancer.Carvacrol is a phenol monoterpene found in aromatic plants specially in Lamiaceae family, which has been evaluated in an experimental model of breast cancer. However, any proposed mechanism based on its antitumor effect has not been reported. In our previous study, carvacrol showed a protective effect on 7,12-dimethylbenz[α]anthracene- (DMBA-) induced breast cancer in female rats. The main objective in this research was to evaluate by using in silico study the carvacrol on HER2, PI3Kα, mTOR, hER-α, PR, and EGFR receptors involved in breast cancer progression by docking analysis, molecular dynamic, and drug-likeness evaluation. A multilevel computational study to evaluate the antitumor potential of carvacrol focusing on the main targets involved in the breast can2020-01-01T00:00:00Z20202026-04-07T17:25:46.041Z2020-11-19T16:57:40ZS-EPMC76072783316308410.1155/2020/8830665