{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["D'Ambrosio E"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["1332-1345"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7610423"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(4)"],"pubmed_abstract":["A leading hypothesis for schizophrenia and related psychotic disorders proposes that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies psychosis in the majority of patients who respond to treatment. Although supported by preclinical findings that prefrontal cortical lesions lead to striatal dopamine dysregulation, the relationship between prefrontal structural volume and striatal dopamine function has not been tested in people with psychosis. We therefore investigated the in vivo relationship between striatal dopamine synthesis capacity and prefrontal grey matter volume in treatment-responsive patients with psychosis, and compared them to treatment non-responsive patients, where dopaminergic mechanisms are not thought to be central. Forty patients wit"],"journal":["Molecular psychiatry"],"pubmed_title":["The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal <sup>18</sup>F-DOPA PET and voxel-based morphometry study."],"pmcid":["PMC7610423"],"funding_grant_id":["G0700995","MC_U120097115","094849","MR/N026063/1","1116129","MC-A656-5QD30","MR/N027078/1","094849/Z/10/Z","MR/L022176/1","1375546"],"pubmed_authors":["Pepper F","Turkheimer F","Kim E","Howes OD","Kwon JS","Kotoula V","Jauhar S","Rogdaki M","Kim S","Bonoldi I","D'Ambrosio E","Kempton MJ","Veronese M"],"additional_accession":[]},"is_claimable":false,"name":"The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal <sup>18</sup>F-DOPA PET and voxel-based morphometry study.","description":"A leading hypothesis for schizophrenia and related psychotic disorders proposes that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies psychosis in the majority of patients who respond to treatment. Although supported by preclinical findings that prefrontal cortical lesions lead to striatal dopamine dysregulation, the relationship between prefrontal structural volume and striatal dopamine function has not been tested in people with psychosis. We therefore investigated the in vivo relationship between striatal dopamine synthesis capacity and prefrontal grey matter volume in treatment-responsive patients with psychosis, and compared them to treatment non-responsive patients, where dopaminergic mechanisms are not thought to be central. Forty patients wit","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-04T01:42:52.993Z","creation":"2025-04-04T01:42:52.993Z"},"accession":"S-EPMC7610423","cross_references":{"pubmed":["31690805"],"doi":["10.1038/s41380-019-0570-6"]}}