{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Faria J"],"funding":["European Research Council","Medical Research Council","Wellcome Trust"],"pagination":["289-300"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7610597"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(3)"],"pubmed_abstract":["Highly selective gene expression is a key requirement for antigenic variation in several pathogens, allowing evasion of host immune responses and maintenance of persistent infections<sup>1</sup>. African trypanosomes-parasites that cause lethal diseases in humans and livestock-employ an antigenic variation mechanism that involves monogenic antigen expression from a pool of >2,600 antigen-coding genes<sup>2</sup>. In other eukaryotes, the expression of individual genes can be enhanced by mechanisms involving the juxtaposition of otherwise distal chromosomal loci in the three-dimensional nuclear space<sup>3-5</sup>. However, trypanosomes lack classical enhancer sequences or regulated transcription initiation<sup>6,7</sup>. In this context, it has remained unclear how genome architecture cont"],"journal":["Nature microbiology"],"pubmed_title":["Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes."],"pmcid":["PMC7610597"],"funding_grant_id":["100320/Z/12/Z","100320","MR/K015869/1","715466","203134/Z/16/Z"],"pubmed_authors":["Luzak V","Hutchinson S","Muller LSM","Faria J","Glover L","Horn D","Brink BG","Siegel TN"],"additional_accession":[]},"is_claimable":false,"name":"Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes.","description":"Highly selective gene expression is a key requirement for antigenic variation in several pathogens, allowing evasion of host immune responses and maintenance of persistent infections<sup>1</sup>. African trypanosomes-parasites that cause lethal diseases in humans and livestock-employ an antigenic variation mechanism that involves monogenic antigen expression from a pool of >2,600 antigen-coding genes<sup>2</sup>. In other eukaryotes, the expression of individual genes can be enhanced by mechanisms involving the juxtaposition of otherwise distal chromosomal loci in the three-dimensional nuclear space<sup>3-5</sup>. However, trypanosomes lack classical enhancer sequences or regulated transcription initiation<sup>6,7</sup>. In this context, it has remained unclear how genome architecture cont","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-09T08:25:41.664Z","creation":"2022-02-10T19:23:10.481Z"},"accession":"S-EPMC7610597","cross_references":{"pubmed":["33432154"],"doi":["10.1038/s41564-020-00833-4"]}}