{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Diard M"],"funding":["Swiss National Science Foundation","European Research Council","NIAID NIH HHS"],"pagination":["830-841"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7611113"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(7)"],"pubmed_abstract":["The ability of gut bacterial pathogens to escape immunity by antigenic variation-particularly via changes to surface-exposed antigens-is a major barrier to immune clearance<sup>1</sup>. However, not all variants are equally fit in all environments<sup>2,3</sup>. It should therefore be possible to exploit such immune escape mechanisms to direct an evolutionary trade-off. Here, we demonstrate this phenomenon using Salmonella enterica subspecies enterica serovar Typhimurium (S.Tm). A dominant surface antigen of S.Tm is its O-antigen: a long, repetitive glycan that can be rapidly varied by mutations in biosynthetic pathways or by phase variation<sup>4,5</sup>. We quantified the selective advantage of O-antigen variants in the presence and absence of O-antigen-specific immunoglobulin A and iden"],"journal":["Nature microbiology"],"pubmed_title":["A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants."],"pmcid":["PMC7611113"],"funding_grant_id":["200020","185128","192567","R01 AI041239","176954","173338","180953","159707","310030","865730"],"pubmed_authors":["Hockenberry A","Lentsch V","van der Woude MW","Meier BH","Hardt WD","Viollier PH","Schumann-Moor K","Adamcik J","Arnoldini M","Bonfiglio F","Diard M","Aslani S","Mezzenga R","Hoces D","Slack E","Rocker A","Holst O","Donohue N","Falquet L","Loverdo C","Zandomeneghi G","Stadtmueller BM","Bekele NA","Bohi F","Wuthrich D","Piccoli L","Lanzavecchia A","Egli A","Bakkeren E"],"additional_accession":[]},"is_claimable":false,"name":"A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants.","description":"The ability of gut bacterial pathogens to escape immunity by antigenic variation-particularly via changes to surface-exposed antigens-is a major barrier to immune clearance<sup>1</sup>. However, not all variants are equally fit in all environments<sup>2,3</sup>. It should therefore be possible to exploit such immune escape mechanisms to direct an evolutionary trade-off. Here, we demonstrate this phenomenon using Salmonella enterica subspecies enterica serovar Typhimurium (S.Tm). A dominant surface antigen of S.Tm is its O-antigen: a long, repetitive glycan that can be rapidly varied by mutations in biosynthetic pathways or by phase variation<sup>4,5</sup>. We quantified the selective advantage of O-antigen variants in the presence and absence of O-antigen-specific immunoglobulin A and iden","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-08T04:36:10.641Z","creation":"2022-02-11T13:10:37.327Z"},"accession":"S-EPMC7611113","cross_references":{"pubmed":["34045711"],"doi":["10.1038/s41564-021-00911-1"]}}