{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Turkova A"],"funding":["UKRI MRC DfID Wellcome NIHR Joint Global Health Trials","Medical Research Council","National Institute for Health Research (NIHR)","TB Alliance","Wellcome Trust"],"pagination":["911-922"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7612496"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["386(10)"],"pubmed_abstract":["<h4>Background</h4>Two thirds of children with tuberculosis have nonsevere disease, which may be treatable with a shorter regimen than the current 6-month regimen.<h4>Methods</h4>We conducted an open-label, treatment-shortening, noninferiority trial involving children with nonsevere, symptomatic, presumably drug-susceptible, smear-negative tuberculosis in Uganda, Zambia, South Africa, and India. Children younger than 16 years of age were randomly assigned to 4 months (16 weeks) or 6 months (24 weeks) of standard first-line antituberculosis treatment with pediatric fixed-dose combinations as recommended by the World Health Organization. The primary efficacy outcome was unfavorable status (composite of treatment failure [extension, change, or restart of treatment or tuberculosis recurrence],"],"journal":["The New England journal of medicine"],"pubmed_title":["Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children."],"pmcid":["PMC7612496"],"funding_grant_id":["MR/L004445/1","MC_UU_00004/04","206379/Z/17/Z","MR/R007942/1","MC_UU_12023/27","MC_UU_12023/26"],"pubmed_authors":["Schaaf S","Ssenyonga M","Gie R","Seddon JA","Revathy M","LeBeau K","van der Zalm MM","Crook AM","Grzemska M","McGowan C","Teera J","Swaminathan S","Welch SB","Wills G","Walker S","Mave V","Rohini S","Mwanakalanga H","Shingalili E","Morrison J","Walters E","Zyambo K","Chungu C","Kalumbi MM","Seetha A","Owen-Powell E","Kinikar AA","Banu P","Gibb DM","Tembo C","Baskaran D","Shankar S","Whittaker E","Mwinga A","Wobudeya E","Mulambo S","Vaishnavi S","Darbyshire J","Ssengooba W","Fielding K","Musoke P","Choo L","Clayden P","Workman J","Nagarajan V","SHINE Trial Team","Raichur P","Zulu S","Mboizi RB","Yadav K","Aarnoutse R","Hissar S","Mulenga V","Bhavani PK","Prathiksha G","Abdullah A","Nakalanzi S","Turkova A","Mukisa Williams C","Guru K","Kinikar A","Selvi R","Chipoya T","Goussard P","Mwanyungwi H","Tapse D","Baptiste D","Kumar M","Hesseling AC","Nansamba W","Kumar S","Latha H","Chambela E","Hankombo JM","Baldwin MR","Hoddinott G","Hanna L","Mary S","Singh V","Grandjean L","Nijampurkar A","Donald P","Gunasundari A","Spyer M","Love-Koh J","van Deventer A","Mangalambal G","Malama S","Kapasa M","Revill P","Kesavan A","Sane M","Lungu J","Aravind MA","Kunda S","Supriya R","Ramesh K","Wills GH","Sekar L","Anderson S","Mugyenyi P","Peto T","C Hesseling A","Bharathi S","Gopika S","Balaji S","Ganesh J","Graham SM","Zimba K","Mythily V","Chola D","Chelvi S","Businge G","Elilarasi S","Thomason MJ","McIlleron H","Gomathi NS","Demers AM","Kumar H","Chabala C","Giranab H","Palmer M","Joseph B","Xavier D","Zimri W","Khan S"],"additional_accession":[]},"is_claimable":false,"name":"Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children.","description":"<h4>Background</h4>Two thirds of children with tuberculosis have nonsevere disease, which may be treatable with a shorter regimen than the current 6-month regimen.<h4>Methods</h4>We conducted an open-label, treatment-shortening, noninferiority trial involving children with nonsevere, symptomatic, presumably drug-susceptible, smear-negative tuberculosis in Uganda, Zambia, South Africa, and India. Children younger than 16 years of age were randomly assigned to 4 months (16 weeks) or 6 months (24 weeks) of standard first-line antituberculosis treatment with pediatric fixed-dose combinations as recommended by the World Health Organization. The primary efficacy outcome was unfavorable status (composite of treatment failure [extension, change, or restart of treatment or tuberculosis recurrence],","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T12:54:09.399Z","creation":"2025-04-19T12:54:09.399Z"},"accession":"S-EPMC7612496","cross_references":{"pubmed":["35263517"],"doi":["10.1056/NEJMoa2104535"]}}