{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vihta KD"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["1138-1149"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7612540"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(10)"],"pubmed_abstract":["Background
Escherichia coli bloodstream infections are increasing in the UK and internationally. The evidence base to guide interventions against this major public health concern is small. We aimed to investigate possible drivers of changes in the incidence of E coli bloodstream infection and antibiotic susceptibilities in Oxfordshire, UK, over the past two decades, while stratifying for time since hospital exposure.Methods
In this observational study, we used all available data on E coli bloodstream infections and E coli urinary tract infections (UTIs) from one UK region (Oxfordshire) using anonymised linked microbiological data and hospital electronic health records from the Infections in Oxfordshire Research Database (IORD). We estimated the incidence of infections acros"],"journal":["The Lancet. Infectious diseases"],"pubmed_title":["Trends over time in Escherichia coli bloodstream infections, urinary tract infections, and antibiotic susceptibilities in Oxfordshire, UK, 1998-2016: a study of electronic health records."],"pmcid":["PMC7612540"],"funding_grant_id":["NF-SI-0513-10110","1680447","NF-SI-0515-10056","HDR-9006","NF-SI-0508-10279","CL-2014-13-008","IS-HPU-1112-10041"],"pubmed_authors":["Quan TP","Hayward G","Llewelyn MJ","Butler CC","Wilcox MH","Oakley S","Vihta KD","Davies T","Andersson M","Dunn L","Jeffery K","Mason A","Peto TEA","Hopkins S","Johnson AP","Walker AS","Wyllie DH","Fawcett NJ","Stoesser N","Crook DW","Morgan M"],"additional_accession":[]},"is_claimable":false,"name":"Trends over time in Escherichia coli bloodstream infections, urinary tract infections, and antibiotic susceptibilities in Oxfordshire, UK, 1998-2016: a study of electronic health records.","description":"Background
Escherichia coli bloodstream infections are increasing in the UK and internationally. The evidence base to guide interventions against this major public health concern is small. We aimed to investigate possible drivers of changes in the incidence of E coli bloodstream infection and antibiotic susceptibilities in Oxfordshire, UK, over the past two decades, while stratifying for time since hospital exposure.Methods
In this observational study, we used all available data on E coli bloodstream infections and E coli urinary tract infections (UTIs) from one UK region (Oxfordshire) using anonymised linked microbiological data and hospital electronic health records from the Infections in Oxfordshire Research Database (IORD). We estimated the incidence of infections acros","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2025-04-04T02:25:14.707Z","creation":"2025-04-04T02:25:14.707Z"},"accession":"S-EPMC7612540","cross_references":{"pubmed":["30126643"],"doi":["10.1016/S1473-3099(18)30353-0","10.1016/s1473-3099(18)30353-0"]}}