{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Law ZK"],"funding":["British Heart Foundation","Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["1141-1148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7612544"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["53(4)"],"pubmed_abstract":["<h4>Background</h4>Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic Acid in Intracerebral Haemorrhage-2) randomized controlled trial.<h4>Methods</h4>Consent was provided by patients or by a relative or an independent doctor in incapacitated patients, using a 1-stage (full written consent) or 2-stage (initial brief consent followed by full written consent post-randomization) approach. The computed tomography-to-randomization time according to consent pathways was compared using the Kruskal-Wallis test. Multivariable logistic regression was performed to identify variables associated with onset-to-randomization time of ≤3 hours.<h4>Results</h4>Of "],"journal":["Stroke"],"pubmed_title":["Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial."],"pmcid":["PMC7612544"],"funding_grant_id":["SP/12/2/29422","G108/613","NF-SI-0515-10044","14/190/01","11/129/109","CS/18/2/33719","G1002605","NIHR201309","11_129_109","NIHR128694"],"pubmed_authors":["Lyrer PA","Scutt P","Beridze M","Duley L","Laska AC","Appleton JP","Werring DJ","Bath PM","Shone A","TICH-2 Investigators","England TJ","Collins R","Bereczki D","Thanabalan J","Robinson T","Ciccone A","Law ZK","Egea-Guerrero JJ","Ozturk S","Krishnan K","Sprigg N","Dineen RA","Roberts I","Roffe C","Al-Shahi Salman R","Karlinski M","Christensen H"],"additional_accession":[]},"is_claimable":false,"name":"Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial.","description":"<h4>Background</h4>Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic Acid in Intracerebral Haemorrhage-2) randomized controlled trial.<h4>Methods</h4>Consent was provided by patients or by a relative or an independent doctor in incapacitated patients, using a 1-stage (full written consent) or 2-stage (initial brief consent followed by full written consent post-randomization) approach. The computed tomography-to-randomization time according to consent pathways was compared using the Kruskal-Wallis test. Multivariable logistic regression was performed to identify variables associated with onset-to-randomization time of ≤3 hours.<h4>Results</h4>Of ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-09T19:51:36.846Z","creation":"2025-04-05T09:57:57.24Z"},"accession":"S-EPMC7612544","cross_references":{"pubmed":["34847710"],"doi":["10.1161/STROKEAHA.121.035191"]}}