biostudies-literatureLaw ZKBritish Heart FoundationMedical Research CouncilNational Institute for Health Research (NIHR)1141-1148https://www.ebi.ac.uk/biostudies/studies/S-EPMC7612544biostudies-literatureUnknown53(4)<h4>Background</h4>Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic Acid in Intracerebral Haemorrhage-2) randomized controlled trial.<h4>Methods</h4>Consent was provided by patients or by a relative or an independent doctor in incapacitated patients, using a 1-stage (full written consent) or 2-stage (initial brief consent followed by full written consent post-randomization) approach. The computed tomography-to-randomization time according to consent pathways was compared using the Kruskal-Wallis test. Multivariable logistic regression was performed to identify variables associated with onset-to-randomization time of ≤3 hours.<h4>Results</h4>Of StrokeBrief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial.PMC7612544SP/12/2/29422G108/613NF-SI-0515-1004414/190/0111/129/109CS/18/2/33719G1002605NIHR20130911_129_109NIHR128694Lyrer PAScutt PBeridze MDuley LLaska ACAppleton JPWerring DJBath PMShone ATICH-2 InvestigatorsEngland TJCollins RBereczki DThanabalan JRobinson TCiccone ALaw ZKEgea-Guerrero JJOzturk SKrishnan KSprigg NDineen RARoberts IRoffe CAl-Shahi Salman RKarlinski MChristensen HfalseBrief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial.<h4>Background</h4>Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic Acid in Intracerebral Haemorrhage-2) randomized controlled trial.<h4>Methods</h4>Consent was provided by patients or by a relative or an independent doctor in incapacitated patients, using a 1-stage (full written consent) or 2-stage (initial brief consent followed by full written consent post-randomization) approach. The computed tomography-to-randomization time according to consent pathways was compared using the Kruskal-Wallis test. Multivariable logistic regression was performed to identify variables associated with onset-to-randomization time of ≤3 hours.<h4>Results</h4>Of 2022-01-01T00:00:00Z2022 Apr2026-05-09T19:51:36.846Z2025-04-05T09:57:57.24ZS-EPMC76125443484771010.1161/STROKEAHA.121.035191