{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Armstrong AG"],"funding":["Wellcome Trust"],"pagination":["717-730"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7612903"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(6)"],"pubmed_abstract":["In quiet environments, hearing aids improve the perception of low-intensity sounds. However, for high-intensity sounds in background noise, the aids often fail to provide a benefit to the wearer. Here, using large-scale single-neuron recordings from hearing-impaired gerbils-an established animal model of human hearing-we show that hearing aids restore the sensitivity of neural responses to speech, but not their selectivity. Rather than reflecting a deficit in supra-threshold auditory processing, the low selectivity is a consequence of hearing-aid compression (which decreases the spectral and temporal contrasts of incoming sound) and amplification (which distorts neural responses, regardless of whether hearing is impaired). Processing strategies that avoid the trade-off between neural sensitivity and selectivity should improve the performance of hearing aids."],"journal":["Nature biomedical engineering"],"pubmed_title":["Compression and amplification algorithms in hearing aids impair the selectivity of neural responses to speech."],"pmcid":["PMC7612903"],"funding_grant_id":["200942/Z/16/Z","200942"],"pubmed_authors":["Lam CC","Sabesan S","Lesica NA","Armstrong AG"],"additional_accession":[]},"is_claimable":false,"name":"Compression and amplification algorithms in hearing aids impair the selectivity of neural responses to speech.","description":"In quiet environments, hearing aids improve the perception of low-intensity sounds. However, for high-intensity sounds in background noise, the aids often fail to provide a benefit to the wearer. Here, using large-scale single-neuron recordings from hearing-impaired gerbils-an established animal model of human hearing-we show that hearing aids restore the sensitivity of neural responses to speech, but not their selectivity. Rather than reflecting a deficit in supra-threshold auditory processing, the low selectivity is a consequence of hearing-aid compression (which decreases the spectral and temporal contrasts of incoming sound) and amplification (which distorts neural responses, regardless of whether hearing is impaired). Processing strategies that avoid the trade-off between neural sensitivity and selectivity should improve the performance of hearing aids.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-06-02T21:51:36.666Z","creation":"2025-02-18T23:36:17.167Z"},"accession":"S-EPMC7612903","cross_references":{"pubmed":["33941898"],"doi":["10.1038/s41551-021-00707-y"]}}