{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Diskin C"],"funding":["European Research Council","Science Foundation Ireland","EC | European Regional Development Fund","Wellcome Trust"],"pagination":["2561-2569"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7613254"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["207(10)"],"pubmed_abstract":["PGs are important proinflammatory lipid mediators, the significance of which is highlighted by the widespread and efficacious use of nonsteroidal anti-inflammatory drugs in the treatment of inflammation. 4-Octyl itaconate (4-OI), a derivative of the Krebs cycle-derived metabolite itaconate, has recently garnered much interest as an anti-inflammatory agent. In this article, we show that 4-OI limits PG production in murine macrophages stimulated with the TLR1/2 ligand Pam3CSK4. This decrease in PG secretion is due to a robust suppression of cyclooxygenase 2 (COX2) expression by 4-OI, with both mRNA and protein levels decreased. Dimethyl fumarate, a fumarate derivative used in the treatment of multiple sclerosis, with properties similar to itaconate, replicated the phenotype observed with 4-O"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages."],"pmcid":["PMC7613254"],"funding_grant_id":["205455","834370","109443","109443/Z/15/Z","12/IA/ 1531"],"pubmed_authors":["O'Neill LAJ","Corcoran SE","Zaslona Z","Diskin C","O'Donnell VB","Zotta A","Tyrrell VJ"],"additional_accession":[]},"is_claimable":false,"name":"4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages.","description":"PGs are important proinflammatory lipid mediators, the significance of which is highlighted by the widespread and efficacious use of nonsteroidal anti-inflammatory drugs in the treatment of inflammation. 4-Octyl itaconate (4-OI), a derivative of the Krebs cycle-derived metabolite itaconate, has recently garnered much interest as an anti-inflammatory agent. In this article, we show that 4-OI limits PG production in murine macrophages stimulated with the TLR1/2 ligand Pam3CSK4. This decrease in PG secretion is due to a robust suppression of cyclooxygenase 2 (COX2) expression by 4-OI, with both mRNA and protein levels decreased. Dimethyl fumarate, a fumarate derivative used in the treatment of multiple sclerosis, with properties similar to itaconate, replicated the phenotype observed with 4-O","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T02:26:28.53Z","creation":"2025-02-19T02:27:01.614Z"},"accession":"S-EPMC7613254","cross_references":{"pubmed":["34635585"],"doi":["10.4049/jimmunol.2100488"]}}