{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lallyett C"],"funding":["Medical Research Council","Wellcome Trust","Lundbeck Foundation"],"pagination":["322-327"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7613302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(7)"],"pubmed_abstract":["<h4>Objective</h4>Targeted electrical energy applied to wounds has been shown to improve wound-healing rates. However, the mechanisms are poorly understood. The aim of this study was to identify genes that are responsive to electrical stimulation (ES) in healthy subjects with undamaged skin.<h4>Methods</h4>To achieve this objective, study authors used a small, noninvasive ES medical device to deliver a continuous, specific, set sequence of electrical energy impulses over a 48-hour period to the skin of healthy volunteers and compared resultant gene expression by microarray analysis.<h4>Main results</h4>Application of this specific ES resulted in differential expression of 105 genes, the majority of which were down-regulated. Postmicroarray analyses revealed there was commonality with a sma"],"journal":["Advances in skin & wound care"],"pubmed_title":["Changes in S100 Proteins Identified in Healthy Skin following Electrical Stimulation: Relevance for Wound Healing."],"pmcid":["PMC7613302"],"funding_grant_id":["110126/Z/15/Z","1066598","203128","R198-2015-207"],"pubmed_authors":["Nielson RH","Kadler KE","Kjaer M","Zeef LAH","Yeung CC","Chapman-Jones D","Lallyett C"],"additional_accession":[]},"is_claimable":false,"name":"Changes in S100 Proteins Identified in Healthy Skin following Electrical Stimulation: Relevance for Wound Healing.","description":"<h4>Objective</h4>Targeted electrical energy applied to wounds has been shown to improve wound-healing rates. However, the mechanisms are poorly understood. The aim of this study was to identify genes that are responsive to electrical stimulation (ES) in healthy subjects with undamaged skin.<h4>Methods</h4>To achieve this objective, study authors used a small, noninvasive ES medical device to deliver a continuous, specific, set sequence of electrical energy impulses over a 48-hour period to the skin of healthy volunteers and compared resultant gene expression by microarray analysis.<h4>Main results</h4>Application of this specific ES resulted in differential expression of 105 genes, the majority of which were down-regulated. Postmicroarray analyses revealed there was commonality with a sma","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-04-26T13:03:53.951Z","creation":"2025-02-19T04:38:12.746Z"},"accession":"S-EPMC7613302","cross_references":{"pubmed":["29923902"],"doi":["10.1097/01.asw.0000533722.06780.03","10.1097/01.ASW.0000533722.06780.03"]}}