biostudies-literatureLallyett CMedical Research CouncilWellcome TrustLundbeck Foundation322-327https://www.ebi.ac.uk/biostudies/studies/S-EPMC7613302biostudies-literatureUnknown31(7)<h4>Objective</h4>Targeted electrical energy applied to wounds has been shown to improve wound-healing rates. However, the mechanisms are poorly understood. The aim of this study was to identify genes that are responsive to electrical stimulation (ES) in healthy subjects with undamaged skin.<h4>Methods</h4>To achieve this objective, study authors used a small, noninvasive ES medical device to deliver a continuous, specific, set sequence of electrical energy impulses over a 48-hour period to the skin of healthy volunteers and compared resultant gene expression by microarray analysis.<h4>Main results</h4>Application of this specific ES resulted in differential expression of 105 genes, the majority of which were down-regulated. Postmicroarray analyses revealed there was commonality with a smaAdvances in skin & wound careChanges in S100 Proteins Identified in Healthy Skin following Electrical Stimulation: Relevance for Wound Healing.PMC7613302110126/Z/15/Z1066598203128R198-2015-207Nielson RHKadler KEKjaer MZeef LAHYeung CCChapman-Jones DLallyett CfalseChanges in S100 Proteins Identified in Healthy Skin following Electrical Stimulation: Relevance for Wound Healing.<h4>Objective</h4>Targeted electrical energy applied to wounds has been shown to improve wound-healing rates. However, the mechanisms are poorly understood. The aim of this study was to identify genes that are responsive to electrical stimulation (ES) in healthy subjects with undamaged skin.<h4>Methods</h4>To achieve this objective, study authors used a small, noninvasive ES medical device to deliver a continuous, specific, set sequence of electrical energy impulses over a 48-hour period to the skin of healthy volunteers and compared resultant gene expression by microarray analysis.<h4>Main results</h4>Application of this specific ES resulted in differential expression of 105 genes, the majority of which were down-regulated. Postmicroarray analyses revealed there was commonality with a sma2018-01-01T00:00:00Z2018 Jul2025-04-26T13:03:53.951Z2025-02-19T04:38:12.746ZS-EPMC76133022992390210.1097/01.asw.0000533722.06780.0310.1097/01.ASW.0000533722.06780.03