{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carter P"],"funding":["Cancer Research UK","British Heart Foundation","Medical Research Council","Wellcome Trust"],"pagination":["2113-2123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7613623"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(10)"],"pubmed_abstract":["<h4>Background</h4>Coffee contains many bioactive chemicals and associations with cancer have been reported in observational studies. In this Mendelian randomisation (MR) study we investigated the causal associations of coffee consumption with a broad range of cancers.<h4>Materials and methods</h4>Twelve independent genetic variants proxied coffee consumption. Genetically-predicted risk of any cancer (59,647 cases) and 22 site-specific cancers was estimated in European-descent individuals in UK Biobank. Univariable and multivariable MR analyses were conducted.<h4>Results</h4>Genetically-predicted coffee consumption was not associated with risk of any cancer in the main analysis (OR 1.05, 95% CI 0.98-1.14, p = 0.183) but was associated with an increased risk of digestive system cancer (OR 1.28, 95% CI 1.09-1.51, p = 0.003), driven by a strong association with oesophageal cancer (OR 2.79, 95% CI 1.73-4.50, p = 2.5×10<sup>-5</sup>). This association was consistent after adjustment for genetically-predicted body mass index, smoking and alcohol consumption. There was no strong evidence supporting a causal relationship between genetically-predicted coffee consumption and the majority of cancers studied. However, genetically-predicted coffee consumption was associated with increased risk of multiple myeloma (OR 2.25, 95% CI 1.30-3.89, p = 0.004) and reduced ovarian cancer risk (OR 0.63, 95% CI 0.43-0.93, p = 0.020).<h4>Conclusions</h4>This MR study provides strong support for a causal association of coffee consumption with oesophageal cancer, but not for the majority of cancer types, and the underlying mechanisms require investigation."],"journal":["Clinical nutrition (Edinburgh, Scotland)"],"pubmed_title":["Coffee consumption and cancer risk: a Mendelian randomisation study."],"pmcid":["PMC7613623"],"funding_grant_id":["C18281/A19169","MC_PC_17228","RG/13/13/30194","CH/12/2/29428","RG/18/13/33946","204623/Z/16/Z","MC_QA137853","MC_UU_00002/7","HDR-9004","204623"],"pubmed_authors":["Yuan S","Kar S","Carter P","Vithayathil M","Mason AM","Burgess S","Larsson SC"],"additional_accession":[]},"is_claimable":false,"name":"Coffee consumption and cancer risk: a Mendelian randomisation study.","description":"<h4>Background</h4>Coffee contains many bioactive chemicals and associations with cancer have been reported in observational studies. In this Mendelian randomisation (MR) study we investigated the causal associations of coffee consumption with a broad range of cancers.<h4>Materials and methods</h4>Twelve independent genetic variants proxied coffee consumption. Genetically-predicted risk of any cancer (59,647 cases) and 22 site-specific cancers was estimated in European-descent individuals in UK Biobank. Univariable and multivariable MR analyses were conducted.<h4>Results</h4>Genetically-predicted coffee consumption was not associated with risk of any cancer in the main analysis (OR 1.05, 95% CI 0.98-1.14, p = 0.183) but was associated with an increased risk of digestive system cancer (OR 1.28, 95% CI 1.09-1.51, p = 0.003), driven by a strong association with oesophageal cancer (OR 2.79, 95% CI 1.73-4.50, p = 2.5×10<sup>-5</sup>). This association was consistent after adjustment for genetically-predicted body mass index, smoking and alcohol consumption. There was no strong evidence supporting a causal relationship between genetically-predicted coffee consumption and the majority of cancers studied. However, genetically-predicted coffee consumption was associated with increased risk of multiple myeloma (OR 2.25, 95% CI 1.30-3.89, p = 0.004) and reduced ovarian cancer risk (OR 0.63, 95% CI 0.43-0.93, p = 0.020).<h4>Conclusions</h4>This MR study provides strong support for a causal association of coffee consumption with oesophageal cancer, but not for the majority of cancer types, and the underlying mechanisms require investigation.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-05-08T03:20:03.81Z","creation":"2025-02-19T04:38:59.004Z"},"accession":"S-EPMC7613623","cross_references":{"pubmed":["36067583"],"doi":["10.1016/j.clnu.2022.08.019"]}}