{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nandi T"],"funding":["Intramural NIH HHS","NIMH NIH HHS","National Institutes of Health","European Commission","Royal Society","Lundbeck Foundation","UK Research and Innovation","Medical Research Council","NIHR Oxford Biomedical Research Centre","Horizon 2020","National Institute for Health Research (NIHR)","National Institute for Health and Care Research","Lundbeckfonden","Wellcome Trust"],"pagination":["1153-1162"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7613675"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(5)"],"pubmed_abstract":["Background and objective
Transcranial direct current stimulation (tDCS) has wide ranging applications in neuro-behavioural and physiological research, and in neurological rehabilitation. However, it is currently limited by substantial inter-subject variability in responses, which may be explained, at least in part, by anatomical differences that lead to variability in the electric field (E-field) induced in the cortex. Here, we tested whether the variability in the E-field in the stimulated cortex during anodal tDCS, estimated using computational simulations, explains the variability in tDCS induced changes in GABA, a neurophysiological marker of stimulation effect.Methods
Data from five previously conducted MRS studies were combined. The anode was placed over the left prim"],"journal":["Brain stimulation"],"pubmed_title":["tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel."],"pmcid":["PMC7613675"],"funding_grant_id":["203139/Z/16/Z","R244-2017-196","102584","731827","ZIA-MH002781","203139","102584/Z/13/Z","MR/W008939/1","ZIA-MH002782","110027/Z/15/Z","NIHR-INF-1315","RF1 MH117428","ZIA MH002782","R360-2021-395","1RF1MH117428-01A1","ZIA MH002781","MC_UU_00003/4","R313-2019-622"],"pubmed_authors":["Bachtiar V","Berrington A","Johansen-Berg H","Barron HC","Johnstone A","Kolasinski J","Puonti O","Winkler AM","Stagg CJ","Clarke WT","Hinson EL","Hanayik T","Thielscher A","Nandi T","Nettekoven C"],"additional_accession":[]},"is_claimable":false,"name":"tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel.","description":"Background and objective
Transcranial direct current stimulation (tDCS) has wide ranging applications in neuro-behavioural and physiological research, and in neurological rehabilitation. However, it is currently limited by substantial inter-subject variability in responses, which may be explained, at least in part, by anatomical differences that lead to variability in the electric field (E-field) induced in the cortex. Here, we tested whether the variability in the E-field in the stimulated cortex during anodal tDCS, estimated using computational simulations, explains the variability in tDCS induced changes in GABA, a neurophysiological marker of stimulation effect.Methods
Data from five previously conducted MRS studies were combined. The anode was placed over the left prim","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep-Oct","modification":"2025-04-04T02:25:59.757Z","creation":"2024-11-19T16:21:29.335Z"},"accession":"S-EPMC7613675","cross_references":{"pubmed":["35988862"],"doi":["10.1016/j.brs.2022.07.049"]}}