{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Plangger I"],"funding":["Center for Molecular Biosciences, University of Innsbruck","Austrian Science Fund FWF","European Research Council"],"pagination":["7151-7156"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7613685"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(39)"],"pubmed_abstract":["We present the first total synthesis of eight <i>ent</i>-pimaranes via a short and enantioselective route (11-16 steps). Key features of the divergent synthesis are a Sharpless asymmetric dihydroxylation, a Brønsted acid catalyzed cationic bicyclization, and a mild Rh-catalyzed arene hydrogenation for rapid access to a late synthetic branching point. From there on, selective functional group manipulations enable the synthesis of <i>ent</i>-pimaranes bearing different modifications in the A- and C-rings."],"journal":["Organic letters"],"pubmed_title":["Short, Divergent, and Enantioselective Total Synthesis of Bioactive <i>ent</i>-Pimaranes."],"pmcid":["PMC7613685"],"funding_grant_id":["P 31023","101000060"],"pubmed_authors":["Plangger I","Wurst K","Magauer T"],"additional_accession":[]},"is_claimable":false,"name":"Short, Divergent, and Enantioselective Total Synthesis of Bioactive <i>ent</i>-Pimaranes.","description":"We present the first total synthesis of eight <i>ent</i>-pimaranes via a short and enantioselective route (11-16 steps). Key features of the divergent synthesis are a Sharpless asymmetric dihydroxylation, a Brønsted acid catalyzed cationic bicyclization, and a mild Rh-catalyzed arene hydrogenation for rapid access to a late synthetic branching point. From there on, selective functional group manipulations enable the synthesis of <i>ent</i>-pimaranes bearing different modifications in the A- and C-rings.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T02:26:05.556Z","creation":"2025-04-04T02:26:05.556Z"},"accession":"S-EPMC7613685","cross_references":{"pubmed":["36170466"],"doi":["10.1021/acs.orglett.2c02843"]}}