{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Torrens L"],"funding":["Cancer Research UK","Equipe labellisee par la Ligue Nationale Contre le Cancer","National Institutes of Health","Bristol-Myers Squibb (BMS)","Departament d&apos;Empresa i Coneixement, Generalitat de Catalunya","Generalitat de Catalunya","Institut National de la Santé et de la Recherche Médicale (Inserm)","Deutsche Forschungsgemeinschaft","Instituto de Salud Carlos III","Gilead Research Scholars (GRS)","Samuel Waxman Cancer Research Foundation (SWCRF)","Instituto de Salud Carlos III (ISCIII)","Generalitat de Catalunya (Government of Catalonia)","Tisch Cancer Institute Grant","Asociación Española para el Estudio del Hígado","Asociación Española para el Estudio del Hígado (AEEH)","Deutsche Forschungsgemeinschaft (DFG)","Ministerio de Ciencia e Innovación (MICINN)","Bristol-Myers Squibb","Fondazione AIRC per la Ricerca sul Cancro","Gilead Research Scholars","National Institutes of Health (NIH)","Labex OncoImmunology Investissement d'Avenir","U.S. Department of Defense (DOD)","Institut National de la Santé et de la Recherche Médicale","Fundación Científica Asociación Española Contra el Cáncer (AECC)","Departament d'Empresa i Coneixement, Generalitat de Catalunya (Ministry of Business and Knowledge, Government of Catalonia)","Samuel Waxman Cancer Research Foundation","Ministerio de Ciencia e Innovación","U.S. Department of Defense","Fundación Científica Asociación Española Contra el Cáncer","Labex OncoImmunology Investissement d&apos;Avenir"],"pagination":["4509-4520"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7613712"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(20)"],"pubmed_abstract":["<h4>Purpose</h4>Mongolia has the world's highest incidence of hepatocellular carcinoma (HCC), with ∼100 cases/100,000 inhabitants, although the reasons for this have not been thoroughly delineated.<h4>Experimental design</h4>We performed a molecular characterization of Mongolian (n = 192) compared with Western (n = 187) HCCs by RNA sequencing and whole-exome sequencing to unveil distinct genomic and transcriptomic features associated with environmental factors in this population.<h4>Results</h4>Mongolian patients were younger, with higher female prevalence, and with predominantly HBV-HDV coinfection etiology. Mongolian HCCs presented significantly higher rates of protein-coding mutations (121 vs. 70 mutations per tumor in Western), and in specific driver HCC genes (i.e., APOB and TSC2). Fo"],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents."],"pmcid":["PMC7613712"],"funding_grant_id":["R01 DK128289-01","PI15/00151 and PI18/00079","HA 8754/1-1","C9380/A26813","IFI18/00006","SGR-1358","26813","PID2019-105378RB-I00","P30 CA196521","2017_SGR_1753","CERCA Programme","PI16/00111 and PI19/00036","CA150272P3"],"pubmed_authors":["Taik P","Leonel T","Haber PK","Wang H","Sia D","Esteban-Fabro R","Torrecilla S","Taivanbaatar E","Leow WQ","Villanueva A","Maeda M","Montironi C","Neely J","Perez-Del-Pulgar S","Camprecios G","Thung S","Zucman-Rossi J","Chinburen J","Enkhbold C","Llovet JM","Garcia-Lopez M","Torrens L","Puigvehi M","Varadarajan AR","Yerbolat A","Roayaie S","Torres-Martin M","Forns X","Letouze E","Uzilov A"],"additional_accession":[]},"is_claimable":false,"name":"Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents.","description":"<h4>Purpose</h4>Mongolia has the world's highest incidence of hepatocellular carcinoma (HCC), with ∼100 cases/100,000 inhabitants, although the reasons for this have not been thoroughly delineated.<h4>Experimental design</h4>We performed a molecular characterization of Mongolian (n = 192) compared with Western (n = 187) HCCs by RNA sequencing and whole-exome sequencing to unveil distinct genomic and transcriptomic features associated with environmental factors in this population.<h4>Results</h4>Mongolian patients were younger, with higher female prevalence, and with predominantly HBV-HDV coinfection etiology. Mongolian HCCs presented significantly higher rates of protein-coding mutations (121 vs. 70 mutations per tumor in Western), and in specific driver HCC genes (i.e., APOB and TSC2). Fo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T22:37:18.727Z","creation":"2025-04-07T10:23:12.342Z"},"accession":"S-EPMC7613712","cross_references":{"pubmed":["35998012"],"doi":["10.1158/1078-0432.CCR-22-0632","10.1158/1078-0432.ccr-22-0632"]}}