{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Plomin R"],"funding":["Medical Research Council"],"pubmed_abstract":["The DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for attention-deficit/hyperactivity disorder and neuroticism moderate associations between parent reports of their children's environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study. Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respecti"],"journal":["Development and psychopathology"],"pagination":["1-11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7613991"],"repository":["biostudies-literature"],"pubmed_title":["Gene-environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?"],"pmcid":["PMC7613991"],"funding_grant_id":["G0901245","MR/M021475/1"],"pubmed_authors":["Gidziela A","von Stumm S","Malanchini M","Plomin R"],"additional_accession":[]},"is_claimable":false,"name":"Gene-environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?","description":"The DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for attention-deficit/hyperactivity disorder and neuroticism moderate associations between parent reports of their children's environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study. Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respecti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-18T12:17:18.826Z","creation":"2025-04-06T21:49:59.532Z"},"accession":"S-EPMC7613991","cross_references":{"pubmed":["36148872"],"doi":["10.1017/S0954579422000931","10.1017/s0954579422000931"]}}