{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khodabukus A"],"funding":["NIBIB NIH HHS","NCATS NIH HHS","NIA NIH HHS","NHLBI NIH HHS","Medical Research Council","NIAMS NIH HHS","Wellcome Trust"],"pagination":["eabn9074"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614064"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(666)"],"pubmed_abstract":["Musculoskeletal injuries and disorders are the leading cause of physical disability worldwide and a considerable socioeconomic burden. The lack of effective therapies has driven the development of novel bioengineering approaches that have recently started to gain clinical approvals. In this review, we first discuss the self-repair capacity of the musculoskeletal tissues and describe causes of musculoskeletal dysfunction. We then review the development of novel biomaterial, immunomodulatory, cellular, and gene therapies to treat musculoskeletal disorders. Last, we consider the recent regulatory changes and future areas of technological progress that can accelerate translation of these therapies to clinical practice."],"journal":["Science translational medicine"],"pubmed_title":["Translating musculoskeletal bioengineering into tissue regeneration therapies."],"pmcid":["PMC7614064"],"funding_grant_id":["208858","R01 AG079223","U01 EB028901","R01 AR079223","208858/Z/17/Z","UG3 TR002142","R21 AR078269","U01 HL156348","MR/R015651/1","R01 AR074960","R01 AR070543"],"pubmed_authors":["Guldberg RE","Khodabukus A","Bursac N","Guyer T","Stevens MM","Moore AC"],"additional_accession":[]},"is_claimable":false,"name":"Translating musculoskeletal bioengineering into tissue regeneration therapies.","description":"Musculoskeletal injuries and disorders are the leading cause of physical disability worldwide and a considerable socioeconomic burden. The lack of effective therapies has driven the development of novel bioengineering approaches that have recently started to gain clinical approvals. In this review, we first discuss the self-repair capacity of the musculoskeletal tissues and describe causes of musculoskeletal dysfunction. We then review the development of novel biomaterial, immunomodulatory, cellular, and gene therapies to treat musculoskeletal disorders. Last, we consider the recent regulatory changes and future areas of technological progress that can accelerate translation of these therapies to clinical practice.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T14:29:54.932Z","creation":"2025-04-04T14:29:54.932Z"},"accession":"S-EPMC7614064","cross_references":{"pubmed":["36223445"],"doi":["10.1126/scitranslmed.abn9074"]}}