{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strelitz J"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","Steno Diabetes Center Aarhus (SDCA)","Wellcome Trust","Novo Nordisk Fonden"],"pagination":["730-741"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614211"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(3)"],"pubmed_abstract":["<h4>Aims</h4>Short-term weight loss may lead to remission of type 2 diabetes but the effect of maintained weight loss on cardiovascular disease (CVD) is unknown. We quantified the associations between changes in weight 5 years following a diagnosis of diabetes, and incident CVD events and mortality up to 10 years after diagnosis.<h4>Materials and methods</h4>Observational analysis of the ADDITION-Europe trial of 2730 adults with screen-detected type 2 diabetes from the UK, Denmark and the Netherlands. We defined weight change based on the maintenance at 5 years of weight loss achieved during the year after diabetes diagnosis, and as 5-year overall change in weight. Incident CVD events (n = 229) and all-cause mortality (n = 225) from 5 to 10 years follow-up were ascertained from medical rec"],"journal":["Diabetes, obesity & metabolism"],"pubmed_title":["Association of weight loss and weight loss maintenance following diabetes diagnosis by screening and incidence of cardiovascular disease and all-cause mortality: An observational analysis of the ADDITION-Europe trial."],"pmcid":["PMC7614211"],"funding_grant_id":["NNF17SA0031230-2","RP-PG-0606-1259","MC_UU_12015/1","08/116/300","G061895","NF-SI-0617-10149","G0001164","403","MC_UU_00006/6","405","MC_UU_12015/4","MC_UU_00006/1"],"pubmed_authors":["Griffin SJ","Sharp SJ","Sandbaek A","Vos RC","Strelitz J","Webb DR","Wareham NJ","Rutten GEHM","Witte DR","Khunti K"],"additional_accession":[]},"is_claimable":false,"name":"Association of weight loss and weight loss maintenance following diabetes diagnosis by screening and incidence of cardiovascular disease and all-cause mortality: An observational analysis of the ADDITION-Europe trial.","description":"<h4>Aims</h4>Short-term weight loss may lead to remission of type 2 diabetes but the effect of maintained weight loss on cardiovascular disease (CVD) is unknown. We quantified the associations between changes in weight 5 years following a diagnosis of diabetes, and incident CVD events and mortality up to 10 years after diagnosis.<h4>Materials and methods</h4>Observational analysis of the ADDITION-Europe trial of 2730 adults with screen-detected type 2 diabetes from the UK, Denmark and the Netherlands. We defined weight change based on the maintenance at 5 years of weight loss achieved during the year after diabetes diagnosis, and as 5-year overall change in weight. Incident CVD events (n = 229) and all-cause mortality (n = 225) from 5 to 10 years follow-up were ascertained from medical rec","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T02:25:35.442Z","creation":"2025-04-04T02:25:35.442Z"},"accession":"S-EPMC7614211","cross_references":{"pubmed":["33269535"],"doi":["10.1111/dom.14278"]}}