biostudies-literatureStrelitz JMedical Research CouncilNational Institute for Health Research (NIHR)Steno Diabetes Center Aarhus (SDCA)Wellcome TrustNovo Nordisk Fonden730-741https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614211biostudies-literatureUnknown23(3)<h4>Aims</h4>Short-term weight loss may lead to remission of type 2 diabetes but the effect of maintained weight loss on cardiovascular disease (CVD) is unknown. We quantified the associations between changes in weight 5 years following a diagnosis of diabetes, and incident CVD events and mortality up to 10 years after diagnosis.<h4>Materials and methods</h4>Observational analysis of the ADDITION-Europe trial of 2730 adults with screen-detected type 2 diabetes from the UK, Denmark and the Netherlands. We defined weight change based on the maintenance at 5 years of weight loss achieved during the year after diabetes diagnosis, and as 5-year overall change in weight. Incident CVD events (n = 229) and all-cause mortality (n = 225) from 5 to 10 years follow-up were ascertained from medical recDiabetes, obesity & metabolismAssociation of weight loss and weight loss maintenance following diabetes diagnosis by screening and incidence of cardiovascular disease and all-cause mortality: An observational analysis of the ADDITION-Europe trial.PMC7614211NNF17SA0031230-2RP-PG-0606-1259MC_UU_12015/108/116/300G061895NF-SI-0617-10149G0001164403MC_UU_00006/6405MC_UU_12015/4MC_UU_00006/1Griffin SJSharp SJSandbaek AVos RCStrelitz JWebb DRWareham NJRutten GEHMWitte DRKhunti KfalseAssociation of weight loss and weight loss maintenance following diabetes diagnosis by screening and incidence of cardiovascular disease and all-cause mortality: An observational analysis of the ADDITION-Europe trial.<h4>Aims</h4>Short-term weight loss may lead to remission of type 2 diabetes but the effect of maintained weight loss on cardiovascular disease (CVD) is unknown. We quantified the associations between changes in weight 5 years following a diagnosis of diabetes, and incident CVD events and mortality up to 10 years after diagnosis.<h4>Materials and methods</h4>Observational analysis of the ADDITION-Europe trial of 2730 adults with screen-detected type 2 diabetes from the UK, Denmark and the Netherlands. We defined weight change based on the maintenance at 5 years of weight loss achieved during the year after diabetes diagnosis, and as 5-year overall change in weight. Incident CVD events (n = 229) and all-cause mortality (n = 225) from 5 to 10 years follow-up were ascertained from medical rec2021-01-01T00:00:00Z2021 Mar2025-04-04T02:25:35.442Z2025-04-04T02:25:35.442ZS-EPMC76142113326953510.1111/dom.14278