biostudies-literatureStringaris AMedical Research CouncilNIMH NIH HHSNational Institute for Health Research (NIHR)Wellcome Trust1215-23https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614275biostudies-literatureUnknown172(12)<h4>Objective</h4>The authors examined whether alterations in the brain's reward network operate as a mechanism across the spectrum of risk for depression. They then tested whether these alterations are specific to anhedonia as compared with low mood and whether they are predictive of depressive outcomes.<h4>Method</h4>Functional MRI was used to collect blood-oxygen-level-dependent (BOLD) responses to anticipation of reward in the monetary incentive task in 1,576 adolescents in a community-based sample. Adolescents with current subthreshold depression and clinical depression were compared with matched healthy subjects. In addition, BOLD responses were compared across adolescents with anhedonia, low mood, or both symptoms, cross-sectionally and longitudinally.<h4>Results</h4>Activity in theThe American journal of psychiatryThe Brain's Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample.PMC7614275R01 MH085772-01A1G090185893558R01 MH085772093909IMAGEN ConsortiumKlar ASmolka MNGoodman RYacubian JStrohle AThomsen TNiShiothchain AZysset SGollier-Briant FKlaassen IStruve MWalter HLeonardi-Essmann FVollstaedt-Klein SHohmann CHeath SSteiner SSchmal CRipley TMartinot JLCrombag HKlaassen ALalor EConnolly CFinsterbusch JBuchel CWilliams SBruhl RWerts HParzer PHeinrichs BDalley JAndrew CSpanagel RTheobald DWolke SIhlenfeld AResch FMignon XGrimmer YLueken LPenttila JBanaschewski TRobbins TWZewdie SSchilling CGallinat JPoline JBBokde ALZiesch VZelenika DMann KReed LNees FNymberg CArtiges ELalanne CBricaud ZSpeiser CMoreno MPausova ZHeym NConstant PClarke TKPapadopoulos DHavatzias SBarbot ALudemann KMuller KPalafox CArroyo MIttermann BRapp MRichmond NGaravan HPena YRietschel MPoustka LBarker GJCostafreda SGourlan CLourdusamy ASchirmbeck FWalaszek BStringaris ABuehler MStephens DWolff ESchubert FIvanov NStolzenburg ESpranger THaffner JVulser HStueber KPeng Wong Cde Rover MMallik CCattrell AVestboe ABordas NFlor HThyreau BBromberg UBrunner RHuebner TJones JMar AVidal-Ribas Belil PSchumann GKappel VLoth EMcCabe EDesrivieres SSommer WStacey DHipolata LFrouin VJordan EHeinz ARipke SNewman CSubramaniam NRogers JTopper LLemaitre HLawrence CMolander AConrod PIreland JReuter JSchwartz YMiranda RMennigen EFadai TSmith LPaillere-Martinot MLWhelan RLanzerath DGowland PPaus TGalinowski AHake IRobinson ERomanowski AFuchs BLathrop MfalseThe Brain's Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample.<h4>Objective</h4>The authors examined whether alterations in the brain's reward network operate as a mechanism across the spectrum of risk for depression. They then tested whether these alterations are specific to anhedonia as compared with low mood and whether they are predictive of depressive outcomes.<h4>Method</h4>Functional MRI was used to collect blood-oxygen-level-dependent (BOLD) responses to anticipation of reward in the monetary incentive task in 1,576 adolescents in a community-based sample. Adolescents with current subthreshold depression and clinical depression were compared with matched healthy subjects. In addition, BOLD responses were compared across adolescents with anhedonia, low mood, or both symptoms, cross-sectionally and longitudinally.<h4>Results</h4>Activity in the2015-01-01T00:00:00Z2015 Dec2025-04-04T02:24:59.445Z2024-11-09T12:28:37.636ZS-EPMC76142752608504210.1176/appi.ajp.2015.14101298