{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vulser H"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["832-40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614311"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(10)"],"pubmed_abstract":["<h4>Objective</h4>Neuroimaging findings have been reported in regions of the brain associated with emotion in both adults and adolescents with depression, but few studies have investigated whether such brain alterations can be detected in adolescents with subthreshold depression, a condition at risk for major depressive disorder. In this study, we searched for differences in brain structure at age 14 years in adolescents with subthreshold depression and their relation to depression at age 16 years.<h4>Method</h4>High-resolution structural magnetic resonance imaging was used to assess adolescents with self-reported subthreshold depression (n = 119) and healthy control adolescents (n = 461), all recruited from a community-based sample. Regional gray and white matter volumes were compared acr"],"journal":["Journal of the American Academy of Child and Adolescent Psychiatry"],"pubmed_title":["Subthreshold depression and regional brain volumes in young community adolescents."],"pmcid":["PMC7614311"],"funding_grant_id":["G0901858","G9817803B","093909"],"pubmed_authors":["Bach C","Fauth-Buhler M","Smolka MN","Goodman R","Filippi I","Yacubian J","Strohle A","Gollier-Briant F","Struve M","Ruggeri B","Martinot JL","Connolly C","Buchel C","Bruhl R","Werts H","Dalley J","Andrew C","Spanagel R","Albrecht L","Theobald D","Ihlenfeld A","Vetter N","Massicotte J","Millenet S","Grimmer Y","Hall D","Penttila J","Hubner T","Banaschewski T","Schneider S","Robbins TW","Rodehacke S","Gallinat J","Poline JB","Bokde AL","Ziesch V","Mann K","Reed L","Nees F","Nymberg C","Artiges E","Lalanne C","Bricaud Z","Pausova Z","Heym N","Havatzias S","Muller K","Ittermann B","Rapp M","Garavan H","Rietschel M","Poustka L","Barker GJ","IMAGEN Consortium www imagen-europe com","Schmidt D","Walaszek B","Stringaris A","Stephens D","Ivanov N","Carter D","Vulser H","Stueber K","Mallik C","Cattrell A","Nugent S","Bordas N","Flor H","Thyreau B","Bromberg U","Head K","Jones J","Strache N","Schumann G","Kappel V","Loth E","Desrivieres S","Frouin V","Tahmasebi A","Heinz A","Ripke S","Newman C","Jia T","IMAGEN Consortium (www.imagen-europe.com)","Subramaniam N","Rogers J","Topper L","Lemaitre H","Lawrence C","Conrod P","Ireland J","Reuter J","Schwartz Y","Miranda R","Mennigen E","Fadai T","Smith L","Paillere-Martinot ML","Whelan R","Gowland P","Paus T","Galinowski A","Lathrop M"],"additional_accession":[]},"is_claimable":false,"name":"Subthreshold depression and regional brain volumes in young community adolescents.","description":"<h4>Objective</h4>Neuroimaging findings have been reported in regions of the brain associated with emotion in both adults and adolescents with depression, but few studies have investigated whether such brain alterations can be detected in adolescents with subthreshold depression, a condition at risk for major depressive disorder. In this study, we searched for differences in brain structure at age 14 years in adolescents with subthreshold depression and their relation to depression at age 16 years.<h4>Method</h4>High-resolution structural magnetic resonance imaging was used to assess adolescents with self-reported subthreshold depression (n = 119) and healthy control adolescents (n = 461), all recruited from a community-based sample. Regional gray and white matter volumes were compared acr","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2025-04-04T02:25:01.333Z","creation":"2025-04-04T02:25:01.333Z"},"accession":"S-EPMC7614311","cross_references":{"pubmed":["26407493"],"doi":["10.1016/j.jaac.2015.07.006"]}}