{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wood CM"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["eade1779"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614473"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(690)"],"pubmed_abstract":["Poor outcomes are common in individuals with anxiety and depression, and the brain circuits underlying symptoms and treatment responses remain elusive. To elucidate these neural circuits, experimental studies must specifically manipulate them, which is only possible in animals. Here, we used a chemogenetics strategy involving engineered designer receptors exclusively activated by designer drugs (DREADDs) to activate a region of the marmoset brain that is dysfunctional in human patients with major depressive disorder, called the subcallosal anterior cingulate cortex area 25 (scACC-25). Using this DREADDs system, we identified separate scACC-25 neural circuits that underlie specific components of anhedonia and anxiety in marmosets. Activation of the neural pathway connecting the scACC-25 to "],"journal":["Science translational medicine"],"pubmed_title":["Chemogenetics identifies separate area 25 brain circuits involved in anhedonia and anxiety in marmosets."],"pmcid":["PMC7614473"],"funding_grant_id":["108089","MR/P501992/1","108089/Z/15/Z"],"pubmed_authors":["Cockcroft GJ","Roberts AC","Santangelo AM","Alexander L","Alsio J","Wood CM","McIver L"],"additional_accession":[]},"is_claimable":false,"name":"Chemogenetics identifies separate area 25 brain circuits involved in anhedonia and anxiety in marmosets.","description":"Poor outcomes are common in individuals with anxiety and depression, and the brain circuits underlying symptoms and treatment responses remain elusive. To elucidate these neural circuits, experimental studies must specifically manipulate them, which is only possible in animals. Here, we used a chemogenetics strategy involving engineered designer receptors exclusively activated by designer drugs (DREADDs) to activate a region of the marmoset brain that is dysfunctional in human patients with major depressive disorder, called the subcallosal anterior cingulate cortex area 25 (scACC-25). Using this DREADDs system, we identified separate scACC-25 neural circuits that underlie specific components of anhedonia and anxiety in marmosets. Activation of the neural pathway connecting the scACC-25 to ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T02:25:27.51Z","creation":"2024-11-06T23:20:29.371Z"},"accession":"S-EPMC7614473","cross_references":{"pubmed":["37018416"],"doi":["10.1126/scitranslmed.ade1779"]}}