biostudies-literatureAl-Sawaf OCancer Research UKDeutsche ForschungsgemeinschaftThe Francis Crick InstituteMedical Research CouncilNational Institute for Health Research (NIHR)NCI NIH HHSRosetreesWellcome TrustNovo Nordisk FondenLundbeck Foundation846-858https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614477biostudies-literatureUnknown29(4)Cancer-associated cachexia (CAC) is a major contributor to morbidity and mortality in individuals with non-small cell lung cancer. Key features of CAC include alterations in body composition and body weight. Here, we explore the association between body composition and body weight with survival and delineate potential biological processes and mediators that contribute to the development of CAC. Computed tomography-based body composition analysis of 651 individuals in the TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy (Rx)) study suggested that individuals in the bottom 20th percentile of the distribution of skeletal muscle or adipose tissue area at the time of lung cancer diagnosis, had significantly shorter lung cancer-specific survival and overall survival. This fNature medicineBody composition and lung cancer-associated cachexia in TRACERx.PMC761447724956CC2088MR/W011786/117786CC2041RCCFEL\100099214274/Z/18/Z29569MR/V033077/12534930025MC_UU_12012/1FC001169NNF21OC0071483R272-2017-4040CC1107MC_UU_00014/5211179/Z/18/ZCC1062M781MC_UU_00014/1CC1061R35 CA197449CTRNBC-2022/100001467697427CF-2021-2 117CL-2015-18-009S_360921999CC1119PGL21 10119CC2008U19 CA203654Osman ALitovchenko MBailey CStavrou GKilgour EChristiani DCFraioli FStone RKThakrar RMPilotti CBiswas DSivakumar MDhanda HKPrymas PMcGranahan NIngram PThol KAlzetani AYuan YDuran MVAl-Sawaf OHackshaw ABreen DMDe Sousa PChavan HWilson GARowan AAsif MChaturvedi AGronroos EScarci MLangman GRussell PSunderland MWStephens RCFennell DAAthanasopoulou FNaito YLevi DMartinez-Ruiz CLopez SForster MDGomes FMalima MKerr KMNovasio JKhiroya RBay CShackleford HSummers YBenafif SWatkins TBKNicod JVeeriah SLee SMLitchfield KGrapa ABishop PAerts HJBola SKHoxha ELe Quesne JO'Rahilly SDjearaman MBlack JRMGower NBeg MFHill WBajaj APatrini DBridge CPSpanswick VColliver EPich OTanic MKostoulas NTugwood JSkrzypski MCarter MAbdulJabbar KAng KBlyth KGBakir MADemeulemeester JChen KProli CFernandes NMagness ACollins-Fekete CARathinam STaylor MNEscudero MChowdhry MFGilbert KPawlik PScarlett LJanes SMBegum SSzallasi ZSwanton CSharp AKisistok JChuter DBhayani HBoeing SRammohan KLindsay CRWeiss JLu WTLiu YKhalil MMoore DALiu WKMonk FPatel AJNaceur-Lombardelli CMarrone DToncheva AJordan SShackcloth MJRane JKAngelova MMoss SChee SCollins SPerrimon NHerrero JKassiotis GHobson PPopuri KGrigoriadis KBoleti EOliveira PLeung MLim EScotland MKaufmann TLDulloo SShah MPapadatos-Pastos DBandula SShah PShah RHiley CTZhang HLacson CWilson JCrosbie PBilancia RLeek AQuezada SALeslie RGoldman JWeeden CERoyle GLucas OAhmed ABhakhri KKerr AStewart ASelvaraju KGorman PTufail MRichardson SBeck SFontaine EWong YNSChan KMontero AHayward MCastignani CKanu NZambrana FMastrokalos GKaniu DCheyne HGalvez-Cancino FSaghafinia SChoudhary JRice AWelsh PClark TClipson ADanson SDive CBunkum ASchwarz RFDijkstra KMacKenzie MHolding JWReading JLTotten NCampbell BBHewish MKidd ACDietzen MSattar NHessey SDick CLee CMak RHHartley JAThomas MPearce DRNavani NAbbosh CMatharu GRiley JVeiga CBooth SLester JFNicholson AGKirk APrice GBuderi SIJayanth NNg KWKaramani APanagiotopoulos NRichard CAshford PFalzon MWilson CKadiri SBirkbak NJUng SKACave JNakas AKaragianni DZaccaria SBarbe VAustin SRothwell DGSodha-Ramdeen AKarasaki TAhmad TRichards JAerts HJWLMiddleton GMarafioti TEnfield KSSEnsell LHodgkinson JDSokac MWu YMatos IGShaw JAPuttick CPrimrose LBlackhall FHLowe HLGimeno-Valiente FProcter AJJamal-Hanjani MHynds REVendramin RDoran HKrebs MGPeggs KSGamble SMourikis TPBentham RRamsden ZRaubenheimer HChain BHuebner ARosenthal RVan Loo PMagno NCadieux ELNaidu BWard SLam JMHill MSChervova OJoshi VThakkar KDenner TLawrence DFrankell AMBoyles RPriest LRosenthal MVanloo SPan XTRACERx ConsortiumZhai HRobinson LHoogenboom EMSmith EAmbrose LDevaraj ADiossy MJoseph LGranato FSmith SBrown KBorg ESalgado RNye ECruickshank TLim ELNair AfalseBody composition and lung cancer-associated cachexia in TRACERx.Cancer-associated cachexia (CAC) is a major contributor to morbidity and mortality in individuals with non-small cell lung cancer. Key features of CAC include alterations in body composition and body weight. Here, we explore the association between body composition and body weight with survival and delineate potential biological processes and mediators that contribute to the development of CAC. Computed tomography-based body composition analysis of 651 individuals in the TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy (Rx)) study suggested that individuals in the bottom 20th percentile of the distribution of skeletal muscle or adipose tissue area at the time of lung cancer diagnosis, had significantly shorter lung cancer-specific survival and overall survival. This f2023-01-01T00:00:00Z2023 Apr2026-05-28T16:50:39.832Z2025-02-19T04:16:02.677ZS-EPMC76144773704599710.1038/s41591-023-02232-8