{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Manet C"],"funding":["HHMI-Wellcome International Research Scholarship","Howard Hughes Medical Institute","French Government’s Investissement d’Avenir program, Laboratoire d’Excellence “Integrative Biology of Emerging Infectious Diseases”","Institut Pasteur International Network G4 grant","Wellcome Trust"],"pagination":["384-407"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614898"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(7-8)"],"pubmed_abstract":["Flaviviruses are arthropod-borne viruses, several of which represent emerging or re-emerging pathogens responsible for widespread infections with consequences ranging from asymptomatic seroconversion to severe clinical diseases and congenital developmental deficits. This variability is due to multiple factors including host genetic determinants, the role of which has been investigated in mouse models and human genetic studies. In this review, we provide an overview of the host genes and variants which modify susceptibility or resistance to major mosquito-borne flaviviruses infections in mice and humans."],"journal":["Mammalian genome : official journal of the International Mammalian Genome Society"],"pubmed_title":["Host genetic control of mosquito-borne Flavivirus infections."],"pmcid":["PMC7614898"],"funding_grant_id":["208710/Z/17/Z","ANR-10-LABX-62-IBEID"],"pubmed_authors":["Tawfik A","Sakuntabhai A","Roth C","Cantaert T","Montagutelli X","Manet C"],"additional_accession":[]},"is_claimable":false,"name":"Host genetic control of mosquito-borne Flavivirus infections.","description":"Flaviviruses are arthropod-borne viruses, several of which represent emerging or re-emerging pathogens responsible for widespread infections with consequences ranging from asymptomatic seroconversion to severe clinical diseases and congenital developmental deficits. This variability is due to multiple factors including host genetic determinants, the role of which has been investigated in mouse models and human genetic studies. In this review, we provide an overview of the host genes and variants which modify susceptibility or resistance to major mosquito-borne flaviviruses infections in mice and humans.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-04-18T22:31:38.097Z","creation":"2025-04-07T10:13:59.195Z"},"accession":"S-EPMC7614898","cross_references":{"pubmed":["30167843"],"doi":["10.1007/s00335-018-9775-2"]}}