{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(1)"],"submitter":["Piccolo S"],"pubmed_abstract":["Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and highlight open questions. YAP/TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials."],"journal":["Nature cancer"],"pagination":["9-26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614914"],"repository":["biostudies-literature"],"pubmed_title":["YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches."],"pmcid":["PMC7614914"],"pubmed_authors":["Contessotto P","Cordenonsi M","Piccolo S","Panciera T"],"additional_accession":[]},"is_claimable":false,"name":"YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches.","description":"Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and highlight open questions. YAP/TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-18T22:31:32.242Z","creation":"2025-04-07T10:13:53.036Z"},"accession":"S-EPMC7614914","cross_references":{"pubmed":["36564601"],"doi":["10.1038/s43018-022-00473-z"]}}