biostudies-literatureUnknown4(1)Piccolo SOur understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and highlight open questions. YAP/TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials.Nature cancer9-26https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614914biostudies-literatureYAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches.PMC7614914Contessotto PCordenonsi MPiccolo SPanciera TfalseYAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches.Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and highlight open questions. YAP/TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials.2023-01-01T00:00:00Z2023 Jan2025-04-18T22:31:32.242Z2025-04-07T10:13:53.036ZS-EPMC76149143656460110.1038/s43018-022-00473-z