biostudies-literatureWang LCancer Research UKMinistry of Science and Technology of the People's Republic of ChinaMedical Research CouncilNational Natural Science Foundation of ChinaWellcome TrustNational Key Research and Development Program of China987-998https://www.ebi.ac.uk/biostudies/studies/S-EPMC7614994biostudies-literatureUnknown146(4)High body mass index (BMI) has been associated with an increased risk of several cancers. Evidence relating body fatness, especially based on different anthropometric measures, to risk of major cancers in China from prospective cohort studies is lacking. The prospective China Kadoorie Biobank study recruited 0.5 million adults aged 30-79 years from 10 diverse areas across China during 2004-2008, recording 21,474 incident cancers during 8.95 years of follow-up. BMI, body fat percentage (BFP), waist circumference (WC) and waist-to-hip ratio (WHR) were measured at baseline. We assessed the associations of body fatness with 15 major cancers by calculating Cox regression yielded adjusted hazard ratios (HRs). Each 5 kg/m² increase in BMI was associated with an increased risk of endomeInternational journal of cancerCancer incidence in relation to body fatness among 0.5 million men and women: Findings from the China Kadoorie Biobank.PMC7614994088158/Z/09/Z2011BAI09B01MC_U1376868512016YFC0900500104085815210042016YFC0900501104085/Z/14/Z2016YFC0900504202922/Z/16/Z212946/Z/18/Z202922MC_UU_12026/2088158291868139054081390543MC_UU_00017/181530088Zhang DGuo ZHu YGuo YHu ZZhang JWright NZhang HHu XZhang NSu JZhang LZhang SShen HWalters RRyder PJin GKerosi RSansome SJin JTang ZZeng MHe HXu QTurnbull IHe PHu CHe TLin KXu XFeng SHu RLan JRen XYu MTang AFu ZHan XFu YQin YPang ZFan LCheng LZhou GWei LZhou JKurmi OZhou LKong LChang LZang YChina Kadoorie Biobank Collaborative GroupKartsonaki CZhou WZhou YChang YZhou XLv JMeng FLewington SQian YYu BHuang YYu CTian XLv SMillwood IMeng JWu MDu RLu YWang CWang DClarke RSchmidt DWang HLancaster GWang JWang LGe PWu HQiu ZGilbert SChen ZSun QWang SXie KWang TWu SHill MChen YBian ZWang XChen XSun HGu QDong CWu XLi HChen NYang JLi JYang LChen JKang QRadhakrishnan JLi FChen LChen FMcDonnell JZhong XSherliker PSohoni RSun XWeng MLi LChen BLi MYang XGao RLi XPei PLi YLi STan YGao YDu HIona ALiu HRafiq SLiu JMa LLong HJiang GJiang QMao EPeto RPing Wang NCAvery DHou WLiu YZhai YHacker AHolmes MBennett DCollins RNie QLuo GNing FPan DStevens BZhang YZhang XBoxall RTao RPan RHou CYin LLiu FfalseCancer incidence in relation to body fatness among 0.5 million men and women: Findings from the China Kadoorie Biobank.High body mass index (BMI) has been associated with an increased risk of several cancers. Evidence relating body fatness, especially based on different anthropometric measures, to risk of major cancers in China from prospective cohort studies is lacking. The prospective China Kadoorie Biobank study recruited 0.5 million adults aged 30-79 years from 10 diverse areas across China during 2004-2008, recording 21,474 incident cancers during 8.95 years of follow-up. BMI, body fat percentage (BFP), waist circumference (WC) and waist-to-hip ratio (WHR) were measured at baseline. We assessed the associations of body fatness with 15 major cancers by calculating Cox regression yielded adjusted hazard ratios (HRs). Each 5 kg/m² increase in BMI was associated with an increased risk of endome2020-01-01T00:00:00Z2020 Feb2025-04-19T20:07:03.826Z2025-04-19T20:07:03.826ZS-EPMC76149943111590710.1002/ijc.32394