{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dart RJ"],"funding":["Cancer Research UK","Medical Research Council","The Francis Crick Institute","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["eadh0301"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7615126"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["381(6663)"],"pubmed_abstract":["Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in humans, we characterized the colonic γδ T cell compartment, identifying a diverse repertoire that includes a phenotypically distinct subset coexpressing T cell receptor Vγ4 and the epithelium-binding integrin CD103. This subset was disproportionately diminished and dysregulated in inflammatory bowel disease, whereas on-treatment CD103<sup>+</sup>γδ T cell restoration was associated with sustained inflammatory bowel disease remission. Moreover, CD103<sup>+</sup>Vγ4<sup>+</sup>cell dysregulation and loss were also displayed by humans with germline BTNL3/BTNL8 hypomorphism, which we identified as a risk factor "],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease."],"pmcid":["PMC7615126"],"funding_grant_id":["FC001093","108745","CC2012","094491/Z/10/Z","106292/Z/14/Z","FC001003","108745/Z/15/Z","100156","100156/Z/12/Z","CL-2014-01-005","CC1107","106292"],"pubmed_authors":["Kannambath S","Amar A","East P","Zlatareva I","Theodoridis E","Dart RJ","Hayday AC","Parkes M","Recaldin T","Lamb CA","Mansfield JC","Irving PM","Prescott NJ","Vantourout P"],"additional_accession":[]},"is_claimable":false,"name":"Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease.","description":"Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in humans, we characterized the colonic γδ T cell compartment, identifying a diverse repertoire that includes a phenotypically distinct subset coexpressing T cell receptor Vγ4 and the epithelium-binding integrin CD103. This subset was disproportionately diminished and dysregulated in inflammatory bowel disease, whereas on-treatment CD103<sup>+</sup>γδ T cell restoration was associated with sustained inflammatory bowel disease remission. Moreover, CD103<sup>+</sup>Vγ4<sup>+</sup>cell dysregulation and loss were also displayed by humans with germline BTNL3/BTNL8 hypomorphism, which we identified as a risk factor ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-05-29T00:23:08.988Z","creation":"2024-11-07T04:12:46.415Z"},"accession":"S-EPMC7615126","cross_references":{"pubmed":["37708268"],"doi":["10.1126/science.adh0301"]}}