{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Kanis JA"],"funding":["Medical Research Council"],"pubmed_abstract":["A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX.Introduction
The aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore the relationship of this risk with age, sex, time since baseline and bone mineral density (BMD).Methods
We studied 665,971 men and 1,438,535 women from 64 cohorts in 32 countries followed for a total of 19.5 million person-years. The effect of a prior history of fracture on the risk of any clinical fracture, any osteoporotic fracture, major osteoporotic fracture, and hip fracture alone was examined using an extended Poisson model in each cohort. Cova"],"journal":["Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7615305"],"repository":["biostudies-literature"],"pubmed_title":["Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX."],"pmcid":["PMC7615305"],"funding_grant_id":["MC_PC_21036","MC_UU_00006/1"],"pubmed_authors":["Mellstrom D","Bager CL","Kiel DP","Vila J","Gudnason V","Diez-Perez A","Hollick RJ","Ohlsson C","Leslie WD","Bruyere O","Goldshtein I","Shiroma EJ","Langhammer A","Merlijn T","Zwart M","Harvey NC","Kwok T","Chapurlat R","Ferrari S","Hall J","Hans D","Yoshimura N","Cauley JA","Karlsson MK","Azagra R","Sund R","Akesson KE","Center JR","Lorentzon M","Nordstrom A","Kotowicz MA","Biver E","Wright NC","Sornay-Rendu E","Hoff M","Larijani B","Obermayer-Pietsch B","Tamaki J","Nordstrom P","Szulc P","Christiansen C","Torgerson DJ","Jones G","Lamy O","Swart KMA","Lippuner K","Beaudart C","Huisman M","Koh WP","Kanis JA","Pasco JA","McCloskey EV","Bischoff-Ferrari HA","Wareham NJ","Gluer CC","Elders PJM","Vandenput L","Iki M","Koromani F","Simonsick EM","Orwoll ES","van Schoor NM","Anderson FA","Dufour AB","Goltzman D","Rivadeneira F","Cummings SR","Eisman JA","Johansson H","O'Neill TW","Dawson-Hughes B","Zillikens MC","Ish-Shalom S","Kroger H","Khosla S","Siggeirsdottir K","van Staa TP","Crandall CJ","Fujiwara S","Cooper C","Schott AM","Liu E","da Silva JAP","Fujita Y"],"additional_accession":[]},"is_claimable":false,"name":"Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.","description":"A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX.Introduction
The aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore the relationship of this risk with age, sex, time since baseline and bone mineral density (BMD).Methods
We studied 665,971 men and 1,438,535 women from 64 cohorts in 32 countries followed for a total of 19.5 million person-years. The effect of a prior history of fracture on the risk of any clinical fracture, any osteoporotic fracture, major osteoporotic fracture, and hip fracture alone was examined using an extended Poisson model in each cohort. Cova","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-18T19:55:10.275Z","creation":"2025-04-07T07:44:57.031Z"},"accession":"S-EPMC7615305","cross_references":{"pubmed":["37566158"],"doi":["10.1007/s00198-023-06870-z"]}}