{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Speidel AT"],"funding":["Vetenskapsrådet","European Research Council","Australian Research Council"],"pagination":["e2201378"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7615486"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(21)"],"pubmed_abstract":["Polyurethane-based hydrogels are relatively inexpensive and mechanically robust biomaterials with ideal properties for various applications, including drug delivery, prosthetics, implant coatings, soft robotics, and tissue engineering. In this report, a simple method is presented for synthesizing and casting biocompatible polyurethane-poly(ethylene glycol) (PU-PEG) hydrogels with tunable mechanical properties, nonfouling characteristics, and sustained tolerability as an implantable material or coating. The hydrogels are synthesized via a simple one-pot method using commercially available precursors and low toxicity solvents and reagents, yielding a consistent and biocompatible gel platform primed for long-term biomaterial applications. The mechanical and physical properties of the gels are easily controlled by varying the curing concentration, producing networks with complex shear moduli of 0.82-190 kPa, similar to a range of human soft tissues. When evaluated against a mechanically matched poly(dimethylsiloxane) (PDMS) formulation, the PU-PEG hydrogels demonstrated favorable nonfouling characteristics, including comparable adsorption of plasma proteins (albumin and fibrinogen) and significantly reduced cellular adhesion. Moreover, preliminary murine implant studies reveal a mild foreign body response after 41 days. Due to the tunable mechanical properties, excellent biocompatibility, and sustained in vivo tolerability of these hydrogels, it is proposed that this method offers a simplified platform for fabricating soft PU-based biomaterials for a variety of applications."],"journal":["Advanced healthcare materials"],"pubmed_title":["Tailored Biocompatible Polyurethane-Poly(ethylene glycol) Hydrogels as a Versatile Nonfouling Biomaterial."],"pmcid":["PMC7615486"],"funding_grant_id":["DE190100797","2015‐02904","2020–04443","2020–02583","758705"],"pubmed_authors":["Speidel AT","Caravaca AS","Correia IP","Ziesmer J","Chan YKV","Sotiriou GA","Stevens MM","Wood CS","Roberts DA","Hansel CS","Muller E","Heimgartner J","Olofsson PS","Chivers PRA"],"additional_accession":[]},"is_claimable":false,"name":"Tailored Biocompatible Polyurethane-Poly(ethylene glycol) Hydrogels as a Versatile Nonfouling Biomaterial.","description":"Polyurethane-based hydrogels are relatively inexpensive and mechanically robust biomaterials with ideal properties for various applications, including drug delivery, prosthetics, implant coatings, soft robotics, and tissue engineering. In this report, a simple method is presented for synthesizing and casting biocompatible polyurethane-poly(ethylene glycol) (PU-PEG) hydrogels with tunable mechanical properties, nonfouling characteristics, and sustained tolerability as an implantable material or coating. The hydrogels are synthesized via a simple one-pot method using commercially available precursors and low toxicity solvents and reagents, yielding a consistent and biocompatible gel platform primed for long-term biomaterial applications. The mechanical and physical properties of the gels are easily controlled by varying the curing concentration, producing networks with complex shear moduli of 0.82-190 kPa, similar to a range of human soft tissues. When evaluated against a mechanically matched poly(dimethylsiloxane) (PDMS) formulation, the PU-PEG hydrogels demonstrated favorable nonfouling characteristics, including comparable adsorption of plasma proteins (albumin and fibrinogen) and significantly reduced cellular adhesion. Moreover, preliminary murine implant studies reveal a mild foreign body response after 41 days. Due to the tunable mechanical properties, excellent biocompatibility, and sustained in vivo tolerability of these hydrogels, it is proposed that this method offers a simplified platform for fabricating soft PU-based biomaterials for a variety of applications.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-07-01T03:23:18.852Z","creation":"2025-02-19T01:20:38.811Z"},"accession":"S-EPMC7615486","cross_references":{"pubmed":["35981326"],"doi":["10.1002/adhm.202201378"]}}