{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Giampazolias E"],"funding":["Cancer Research UK","European Research Council","The Francis Crick Institute","Medical Research Council","Wellcome Trust"],"pagination":["428-437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7615937"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["384(6694)"],"pubmed_abstract":["A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D-induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of <i>Bacteroides fragilis</i>, which positively regulates cancer immunity. Our findings indicate a previously unappreciated connection between vitamin D, microbial commensal communitie"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Vitamin D regulates microbiome-dependent cancer immunity."],"pmcid":["PMC7615937"],"funding_grant_id":["CC1061","106973/Z/15/Z","CC2219","106973","CC2090","MC_UU_00025/11","CC1107","216327/Z/19/Z","268670","866028","CC2016","216327"],"pubmed_authors":["Lee JC","Lee S","Simpson B","Chakravarty P","Cardoso A","Biram A","Rodrigues RR","Koufaki MA","Zelenay S","Giampazolias E","Lim KHJ","Reis e Sousa C","Wang P","Castro-Dopico T","Vdovin A","Suarez-Bonnet A","Priestnall SL","Patel S","Kelly G","Childs E","Buck MD","Rogers NC","Piot C","Goldstone R","Palma-Duran SA","Minutti CM","Patil KR","Litchfield K","Jess T","Iseppon A","Poulsen GJ","Blasche S","Lam KC","Frederico B","Goldszmid RS","MacRae JI","Nye E","Omenetti S","Pereira da Costa M"],"additional_accession":[]},"is_claimable":false,"name":"Vitamin D regulates microbiome-dependent cancer immunity.","description":"A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D-induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of <i>Bacteroides fragilis</i>, which positively regulates cancer immunity. Our findings indicate a previously unappreciated connection between vitamin D, microbial commensal communitie","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-03-12T22:43:12.533Z","creation":"2025-08-12T03:04:55.168Z"},"accession":"S-EPMC7615937","cross_references":{"pubmed":["38662827"],"doi":["10.1126/science.adh7954"]}}