{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stockhammer L"],"funding":["Austrian Science Fund FWF"],"pagination":["e202300015"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616101"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(1)"],"pubmed_abstract":["The enantioselective α-functionalisation of glycine Schiff base aryl esters through isothiourea catalysis is successfully demonstrated for 1,6-additions to para-quinone methides (21 examples, up to 95:5 dr and 96:4 er) and 1,4-additions to methylene substituted dicarbonyl or disulfonyl Michael acceptors (17 examples, up to 98:2 er). This nucleophilic organocatalysis approach gives access to a range of α-functionalised α-amino acid derivatives and further transformations of the activated aryl ester group provide a straightforward entry to advanced amino acid-based esters, amides or thioesters."],"journal":["ChemistryEurope"],"pubmed_title":["Isothiourea-Catalyzed Enantioselective Functionalisation of Glycine Schiff Base Aryl Esters via 1,6- and 1,4-Additions."],"pmcid":["PMC7616101"],"funding_grant_id":["P 31784"],"pubmed_authors":["Stockhammer L","Craik R","Cordes DB","Smith AD","Waser M","Monkowius U"],"additional_accession":[]},"is_claimable":false,"name":"Isothiourea-Catalyzed Enantioselective Functionalisation of Glycine Schiff Base Aryl Esters via 1,6- and 1,4-Additions.","description":"The enantioselective α-functionalisation of glycine Schiff base aryl esters through isothiourea catalysis is successfully demonstrated for 1,6-additions to para-quinone methides (21 examples, up to 95:5 dr and 96:4 er) and 1,4-additions to methylene substituted dicarbonyl or disulfonyl Michael acceptors (17 examples, up to 98:2 er). This nucleophilic organocatalysis approach gives access to a range of α-functionalised α-amino acid derivatives and further transformations of the activated aryl ester group provide a straightforward entry to advanced amino acid-based esters, amides or thioesters.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2026-05-29T12:30:17.409Z","creation":"2026-04-08T04:48:17.279Z"},"accession":"S-EPMC7616101","cross_references":{"pubmed":["38882579"],"doi":["10.1002/ceur.202300015"]}}