biostudies-literatureMagyar USwiss National Science Foundation516-525https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616132biostudies-literatureUnknown22(2)<h4>Background</h4>Health-related quality of life (QoL) impairment is common after pulmonary embolism (PE). Whether the severity of the initial PE has an impact on QoL is unknown.<h4>Objectives</h4>To evaluate the association between severity of PE and QoL over time.<h4>Methods</h4>We prospectively assessed PE-specific QoL using the Pulmonary Embolism Quality of Life (lower scores indicate better QoL) questionnaire and generic QoL using the Short Form 36 (higher scores indicate better QoL) questionnaire at baseline and 3 and 12 months in older patients with acute PE. We examined whether QoL differed by PE severity based on hemodynamic status, simplified Pulmonary Embolism Severity Index (sPESI), right ventricular function, and high-sensitivity troponin T in mixed-effects models, adjusting Journal of thrombosis and haemostasis : JTHAssociation between severity of pulmonary embolism and health-related quality of life.PMC7616132122659Mean MTritschler TStalder ORighini MBassetti SSchuetz PBaumgartner CAujesky DMagyar URodondi NfalseAssociation between severity of pulmonary embolism and health-related quality of life.<h4>Background</h4>Health-related quality of life (QoL) impairment is common after pulmonary embolism (PE). Whether the severity of the initial PE has an impact on QoL is unknown.<h4>Objectives</h4>To evaluate the association between severity of PE and QoL over time.<h4>Methods</h4>We prospectively assessed PE-specific QoL using the Pulmonary Embolism Quality of Life (lower scores indicate better QoL) questionnaire and generic QoL using the Short Form 36 (higher scores indicate better QoL) questionnaire at baseline and 3 and 12 months in older patients with acute PE. We examined whether QoL differed by PE severity based on hemodynamic status, simplified Pulmonary Embolism Severity Index (sPESI), right ventricular function, and high-sensitivity troponin T in mixed-effects models, adjusting 2024-01-01T00:00:00Z2024 Feb2025-04-04T02:26:22.324Z2025-04-04T02:26:22.324ZS-EPMC76161323896665910.1016/j.jtha.2023.10.016