biostudies-literatureNab LHealth Data Research UKBarts CharityMedical Research CouncilNational Institute for Health Research (NIHR)National Institute for Health and Care ResearchUK Research and InnovationWellcome Truste5815https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616137biostudies-literatureUnknown33(6)Electronic health records (EHRs) and other administrative health data are increasingly used in research to generate evidence on the effectiveness, safety, and utilisation of medical products and services, and to inform public health guidance and policy. Reproducibility is a fundamental step for research credibility and promotes trust in evidence generated from EHRs. At present, ensuring research using EHRs is reproducible can be challenging for researchers. Research software platforms can provide technical solutions to enhance the reproducibility of research conducted using EHRs. In response to the COVID-19 pandemic, we developed the secure, transparent, analytic open-source software platform OpenSAFELY designed with reproducible research in mind. OpenSAFELY mitigates common barriers to rePharmacoepidemiology and drug safetyOpenSAFELY: A platform for analysing electronic health records designed for reproducible research.PMC7616137COV‐LT‐0009MR/W016729/1MC_PC_20058MGU0504MC_PC_20059COV‐LT2‐0073222097/Z/20/ZCOV-LT2-0073220283/Z/20/ZHDRUK2021.000COV-LT-0009220283224485MC_PC_20030222097MR/V015737/1NIHR135559224485/Z/21/ZMorton CEDavy SHiggins RParry JWalters CEStables CLWilliamson EJMassey JCunningham CBhaskaran KDillingham ISchaffer ALBridges LTomlinson LASmith RMMaude SGoldacre BWard TDeVito NJWalker AWiedemann MButler-Cole BFCSmeeth LMacKenna BAndrews CDHulme WCurtis HMorley JNab LGreen AHester FRentsch CTStokes PEvans DHart LMathur RInglesby PSchultze AO'Dwyer TMehrkar ABates CFisher LCockburn JBacon SHickman GfalseOpenSAFELY: A platform for analysing electronic health records designed for reproducible research.Electronic health records (EHRs) and other administrative health data are increasingly used in research to generate evidence on the effectiveness, safety, and utilisation of medical products and services, and to inform public health guidance and policy. Reproducibility is a fundamental step for research credibility and promotes trust in evidence generated from EHRs. At present, ensuring research using EHRs is reproducible can be challenging for researchers. Research software platforms can provide technical solutions to enhance the reproducibility of research conducted using EHRs. In response to the COVID-19 pandemic, we developed the secure, transparent, analytic open-source software platform OpenSAFELY designed with reproducible research in mind. OpenSAFELY mitigates common barriers to re2024-01-01T00:00:00Z2024 Jun2026-06-04T16:24:34.787Z2025-04-06T01:09:57.071ZS-EPMC76161373878341210.1002/pds.5815