{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gauld OM"],"funding":["European Research Council","UKRI Medical Research Council","Medical Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["2386-2403.e6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616379"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(14)"],"pubmed_abstract":["To investigate which activity patterns in sensory cortex are relevant for perceptual decision-making, we combined two-photon calcium imaging and targeted two-photon optogenetics to interrogate barrel cortex activity during perceptual discrimination. We trained mice to discriminate bilateral whisker deflections and report decisions by licking left or right. Two-photon calcium imaging revealed sparse coding of contralateral and ipsilateral whisker input in layer 2/3, with most neurons remaining silent during the task. Activating pyramidal neurons using two-photon holographic photostimulation evoked a perceptual bias that scaled with the number of neurons photostimulated. This effect was dominated by optogenetic activation of non-coding neurons, which did not show sensory or motor-related activity during task performance. Photostimulation also revealed potent recruitment of cortical inhibition during sensory processing, which strongly and preferentially suppressed non-coding neurons. Our results suggest that a pool of non-coding neurons, selectively suppressed by network inhibition during sensory processing, can be recruited to enhance perception."],"journal":["Neuron"],"pubmed_title":["A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception."],"pmcid":["PMC7616379"],"funding_grant_id":["AdG 695709","MR/T022922/1","PRF 201225","224688","201225","BB/N009835/1","224668","695709"],"pubmed_authors":["Packer AM","Dalgleish HWP","Iuga M","Clark BA","Russell LE","Sacadura F","Gauld OM","Roth A","Hausser M"],"additional_accession":[]},"is_claimable":false,"name":"A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception.","description":"To investigate which activity patterns in sensory cortex are relevant for perceptual decision-making, we combined two-photon calcium imaging and targeted two-photon optogenetics to interrogate barrel cortex activity during perceptual discrimination. We trained mice to discriminate bilateral whisker deflections and report decisions by licking left or right. Two-photon calcium imaging revealed sparse coding of contralateral and ipsilateral whisker input in layer 2/3, with most neurons remaining silent during the task. Activating pyramidal neurons using two-photon holographic photostimulation evoked a perceptual bias that scaled with the number of neurons photostimulated. This effect was dominated by optogenetic activation of non-coding neurons, which did not show sensory or motor-related activity during task performance. Photostimulation also revealed potent recruitment of cortical inhibition during sensory processing, which strongly and preferentially suppressed non-coding neurons. Our results suggest that a pool of non-coding neurons, selectively suppressed by network inhibition during sensory processing, can be recruited to enhance perception.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-19T20:38:12.345Z","creation":"2025-04-19T20:38:12.345Z"},"accession":"S-EPMC7616379","cross_references":{"pubmed":["38729150"],"doi":["10.1016/j.neuron.2024.04.015"]}}