{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang G"],"funding":["Rosetrees’ Trust, UK","Medical Research Council","National Natural Science Foundation of China","Key R&amp;D Program of China"],"pagination":["1112-1122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616489"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["95(12)"],"pubmed_abstract":["<h4>Background</h4>Sleep fragmentation is a persistent problem throughout the course of Parkinson's disease (PD). However, the related neurophysiological patterns and the underlying mechanisms remained unclear.<h4>Method</h4>We recorded subthalamic nucleus (STN) local field potentials (LFPs) using deep brain stimulation (DBS) with real-time wireless recording capacity from 13 patients with PD undergoing a one-night polysomnography recording, 1 month after DBS surgery before initial programming and when the patients were off-medication. The STN LFP features that characterised different sleep stages, correlated with arousal and sleep fragmentation index, and preceded stage transitions during N2 and REM sleep were analysed.<h4>Results</h4>Both beta and low gamma oscillations in non-rapid eye movement (NREM) sleep increased with the severity of sleep disturbance (arousal index (ArI)-beta<sub>NREM</sub>: r=0.9, p=0.0001, sleep fragmentation index (SFI)-beta<sub>NREM</sub>: r=0.6, p=0.0301; SFI-gamma<sub>NREM</sub>: r=0.6, p=0.0324). We next examined the low-to-high power ratio (LHPR), which was the power ratio of theta oscillations to beta and low gamma oscillations, and found it to be an indicator of sleep fragmentation (ArI-LHPR<sub>NREM</sub>: r=-0.8, p=0.0053; ArI-LHPR<sub>REM</sub>: r=-0.6, p=0.0373; SFI-LHPR<sub>NREM</sub>: r=-0.7, p=0.0204; SFI-LHPR<sub>REM</sub>: r=-0.6, p=0.0428). In addition, long beta bursts (>0.25 s) during NREM stage 2 were found preceding the completion of transition to stages with more cortical activities (towards Wake/N1/REM compared with towards N3 (p<0.01)) and negatively correlated with STN spindles, which were detected in STN LFPs with peak frequency distinguishable from long beta bursts (STN spindle: 11.5 Hz, STN long beta bursts: 23.8 Hz), in occupation during NREM sleep (β=-0.24, p<0.001).<h4>Conclusion</h4>Features of STN LFPs help explain neurophysiological mechanisms underlying sleep fragmentations in PD, which can inform new intervention for sleep dysfunction.<h4>Trial registration number</h4>NCT02937727."],"journal":["Journal of neurology, neurosurgery, and psychiatry"],"pubmed_title":["Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson's disease."],"pmcid":["PMC7616489"],"funding_grant_id":["N/A","81527901","2022YFC2405100","MC_UU_00003/2"],"pubmed_authors":["Zhang G","Zhang JG","Tan H","Guo Y","Li L","Yu H","Yin G","Gong C","Zhang Y","Xu S","Chen Y","Hao H","Yuan X"],"additional_accession":[]},"is_claimable":false,"name":"Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson's disease.","description":"<h4>Background</h4>Sleep fragmentation is a persistent problem throughout the course of Parkinson's disease (PD). However, the related neurophysiological patterns and the underlying mechanisms remained unclear.<h4>Method</h4>We recorded subthalamic nucleus (STN) local field potentials (LFPs) using deep brain stimulation (DBS) with real-time wireless recording capacity from 13 patients with PD undergoing a one-night polysomnography recording, 1 month after DBS surgery before initial programming and when the patients were off-medication. The STN LFP features that characterised different sleep stages, correlated with arousal and sleep fragmentation index, and preceded stage transitions during N2 and REM sleep were analysed.<h4>Results</h4>Both beta and low gamma oscillations in non-rapid eye movement (NREM) sleep increased with the severity of sleep disturbance (arousal index (ArI)-beta<sub>NREM</sub>: r=0.9, p=0.0001, sleep fragmentation index (SFI)-beta<sub>NREM</sub>: r=0.6, p=0.0301; SFI-gamma<sub>NREM</sub>: r=0.6, p=0.0324). We next examined the low-to-high power ratio (LHPR), which was the power ratio of theta oscillations to beta and low gamma oscillations, and found it to be an indicator of sleep fragmentation (ArI-LHPR<sub>NREM</sub>: r=-0.8, p=0.0053; ArI-LHPR<sub>REM</sub>: r=-0.6, p=0.0373; SFI-LHPR<sub>NREM</sub>: r=-0.7, p=0.0204; SFI-LHPR<sub>REM</sub>: r=-0.6, p=0.0428). In addition, long beta bursts (>0.25 s) during NREM stage 2 were found preceding the completion of transition to stages with more cortical activities (towards Wake/N1/REM compared with towards N3 (p<0.01)) and negatively correlated with STN spindles, which were detected in STN LFPs with peak frequency distinguishable from long beta bursts (STN spindle: 11.5 Hz, STN long beta bursts: 23.8 Hz), in occupation during NREM sleep (β=-0.24, p<0.001).<h4>Conclusion</h4>Features of STN LFPs help explain neurophysiological mechanisms underlying sleep fragmentations in PD, which can inform new intervention for sleep dysfunction.<h4>Trial registration number</h4>NCT02937727.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-03T05:20:07.785Z","creation":"2026-05-28T03:07:29.296Z"},"accession":"S-EPMC7616489","cross_references":{"pubmed":["38724231"],"doi":["10.1136/jnnp-2023-331979"]}}