{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Odera DO"],"funding":["National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["eabn5993"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616656"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(682)"],"pubmed_abstract":["Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK cells degranulate and release IFN-γ upon stimulation with antibody-opsonized <i>Plasmodium falciparum</i> merozoites. Antibody-dependent NK (Ab-NK) activity was largely strain transcending and enhanced invasion inhibition into erythrocytes. Ab-NK was associated with the successful control of parasitemia after experimental malaria challenge in African adults. In an independent cohort study in children, Ab-NK increased with age, was boosted by concurrent <i>P. falciparum</i> infections, and was associated with a lower risk of clinical episodes of malaria. Nine of the 14 vaccine candidates tested induced Ab-NK, including some less well-characterized antigens: P41, P113, MSP11, RHOPH3, and <i>Pf</i>_11363200. These data highlight an important role of Ab-NK activity in immunity against malaria and provide a potential mechanism for evaluating vaccine candidates."],"journal":["Science translational medicine"],"pubmed_title":["Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria."],"pmcid":["PMC7616656"],"funding_grant_id":["16/136/33","107499"],"pubmed_authors":["Mwai K","Diehl S","Bejon P","Rosenkranz M","Ooko M","Winterberg M","Osier FHA","Kamuya D","Kapulu MC","Kivisi C","Ogutu B","Lowe B","Hoffman SL","Billingsley PF","Ngoto O","Kimathi R","de Laurent Z","Kibinge N","Musasia FK","Frank R","Ngoi JM","Bull PC","Muthui M","Nyangweso G","Omuoyo D","Tuju J","Audi A","Chi PC","Ongas MO","Koskei N","Shangala J","Odera DO","Williams TN","Musembi J","Ongecha J","Otieno E","Murungi L","Marsh K","CHMI-SIKA Study Team","Musyoki J","Richie TL","James ER","Kamuyu G","Njue M","Kimani D","Kinyanjui S","Mwacharo J","Mohammed KS","Marsh V","Kariuki S","Mosobo M","Furle K","Mwongeli J","Sim BKL","Njuguna P","Tarning J","Imwong M","Jao I","Olewe F","Abdi AI","Chege T","Wambua J","Murphy SC","Abebe Y","Mwanga D","Ndungu F","Oloo J","Hodgson SH","Nkumama IN","Makale J","Hamaluba M"],"additional_accession":[]},"is_claimable":false,"name":"Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria.","description":"Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK cells degranulate and release IFN-γ upon stimulation with antibody-opsonized <i>Plasmodium falciparum</i> merozoites. Antibody-dependent NK (Ab-NK) activity was largely strain transcending and enhanced invasion inhibition into erythrocytes. Ab-NK was associated with the successful control of parasitemia after experimental malaria challenge in African adults. In an independent cohort study in children, Ab-NK increased with age, was boosted by concurrent <i>P. falciparum</i> infections, and was associated with a lower risk of clinical episodes of malaria. Nine of the 14 vaccine candidates tested induced Ab-NK, including some less well-characterized antigens: P41, P113, MSP11, RHOPH3, and <i>Pf</i>_11363200. These data highlight an important role of Ab-NK activity in immunity against malaria and provide a potential mechanism for evaluating vaccine candidates.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-06-07T08:14:38.991Z","creation":"2025-04-04T23:49:58.374Z"},"accession":"S-EPMC7616656","cross_references":{"pubmed":["36753561"],"doi":["10.1126/scitranslmed.abn5993"]}}