biostudies-literatureHathaway ABritish Heart FoundationPfizer UK826-838https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616671biostudies-literatureUnknown204(3)Despite significant global morbidity associated with respiratory infection, there is a paucity of data examining the association between severity of non-SARS-CoV-2 respiratory infection and blood group. We analysed a prospective cohort of adults hospitalised in Bristol, UK, from 1 August 2020 to 31 July 2022, including patients with acute respiratory infection (pneumonia [n = 1934] and non-pneumonic lower respiratory tract infection [NP-LRTI] [n = 1184]), a negative SARS-CoV-2 test and known blood group status. The likelihood of cardiovascular complication, survival and hospital admission length was assessed using regression models with group O and RhD-negative status as reference groups. Group A and RhD-positive were over-represented in both pneumonia and NP-LRTI compared to a first-time British journal of haematologyAssociation of ABO and Rhesus blood groups with severe outcomes from non-SARS-CoV-2 respiratory infection: A prospective observational cohort study in Bristol, UK 2020-2022.PMC7616671FS/4yPhD/F/21/34162WI255886FS/4yPhD/F/21/34162BTaylor ZWright LJeenes-Flanagan MAvon CAP Research GroupGonzalez MGWalters ROsborne BAdegbite DRuffino GFox KGrimes CPerkins FLazarus RBellavia MManning NChallen RTaylor ACloake JAntico RSmart LSuppiah SFinn AMaskell NBridgeman EMarlow RHeath RGrace NMaughan KMorrison LMcGuinness SWright JKTilzey GScott ECroxford PGriffiths OValentine GKinney JFleming LToye AMWard LTurner ADanon LClout MHelliker KMaseko ZBrzezinska JGrimwood LKing JMilutinovic KSequenza PHyams CMona TLangdon AChang NQian GVasquez MFriedrich ZRiaz TBayley FMinou KArachchge SNMackay VOliver JMitchell CSzasz-Benczur ZHathaway AMattocks AfalseAssociation of ABO and Rhesus blood groups with severe outcomes from non-SARS-CoV-2 respiratory infection: A prospective observational cohort study in Bristol, UK 2020-2022.Despite significant global morbidity associated with respiratory infection, there is a paucity of data examining the association between severity of non-SARS-CoV-2 respiratory infection and blood group. We analysed a prospective cohort of adults hospitalised in Bristol, UK, from 1 August 2020 to 31 July 2022, including patients with acute respiratory infection (pneumonia [n = 1934] and non-pneumonic lower respiratory tract infection [NP-LRTI] [n = 1184]), a negative SARS-CoV-2 test and known blood group status. The likelihood of cardiovascular complication, survival and hospital admission length was assessed using regression models with group O and RhD-negative status as reference groups. Group A and RhD-positive were over-represented in both pneumonia and NP-LRTI compared to a first-time 2024-01-01T00:00:00Z2024 Mar2026-06-14T05:28:34.247Z2025-04-04T08:22:00.414ZS-EPMC76166713800956110.1111/bjh.19234