biostudies-literatureClarke WTMedical Research CouncilRoyal SocietyWellcome Trust2229-2246https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616727biostudies-literatureUnknown91(6)<h4>Purpose</h4>Dynamic (2D) MRS is a collection of techniques where acquisitions of spectra are repeated under varying experimental or physiological conditions. Dynamic MRS comprises a rich set of contrasts, including diffusion-weighted, relaxation-weighted, functional, edited, or hyperpolarized spectroscopy, leading to quantitative insights into multiple physiological or microstructural processes. Conventional approaches to dynamic MRS analysis ignore the shared information between spectra, and instead proceed by independently fitting noisy individual spectra before modeling temporal changes in the parameters. Here, we propose a universal dynamic MRS toolbox which allows simultaneous fitting of dynamic spectra of arbitrary type.<h4>Methods</h4>A simple user-interface allows information tMagnetic resonance in medicineUniversal dynamic fitting of magnetic resonance spectroscopy.PMC7616727203139/Z/16/Z221933DHF∖R1∖201141215573215573/Z/19/Z225924/Z/22/Z221933/Z/20/ZMR/V034723/1203139203139/A/16/Z225924Ligneul CJbabdi SClarke WTCottaar MIp IBfalseUniversal dynamic fitting of magnetic resonance spectroscopy.<h4>Purpose</h4>Dynamic (2D) MRS is a collection of techniques where acquisitions of spectra are repeated under varying experimental or physiological conditions. Dynamic MRS comprises a rich set of contrasts, including diffusion-weighted, relaxation-weighted, functional, edited, or hyperpolarized spectroscopy, leading to quantitative insights into multiple physiological or microstructural processes. Conventional approaches to dynamic MRS analysis ignore the shared information between spectra, and instead proceed by independently fitting noisy individual spectra before modeling temporal changes in the parameters. Here, we propose a universal dynamic MRS toolbox which allows simultaneous fitting of dynamic spectra of arbitrary type.<h4>Methods</h4>A simple user-interface allows information t2024-01-01T00:00:00Z2024 Jun2026-06-02T03:52:24.438Z2025-04-06T22:45:40.021ZS-EPMC76167273826515210.1002/mrm.30001