{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Appios A"],"funding":["Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["eadp0344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616733"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(99)"],"pubmed_abstract":["Langerhans cells (LCs) are distinct among phagocytes, functioning both as embryo-derived, tissue-resident macrophages in skin innervation and repair and as migrating professional antigen-presenting cells, a function classically assigned to dendritic cells (DCs). Here, we demonstrate that both intrinsic and extrinsic factors imprint this dual identity. Using ablation of embryo-derived LCs in the murine adult skin and tracking differentiation of incoming monocyte-derived replacements, we found intrinsic intraepidermal heterogeneity. We observed that ontogenically distinct monocytes give rise to LCs. Within the epidermis, Jagged-dependent activation of Notch signaling, likely within the hair follicle niche, provided an initial site of LC commitment before metabolic adaptation and survival of monocyte-derived LCs. In the human skin, embryo-derived LCs in newborns retained transcriptional evidence of their macrophage origin, but this was superseded by DC-like immune modules after postnatal expansion. Thus, adaptation to adult skin niches replicates conditioning of LC at birth, permitting repair of the embryo-derived LC network."],"journal":["Science immunology"],"pubmed_title":["Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity."],"pmcid":["PMC7616733"],"funding_grant_id":["109377/Z/15/Z","BB/T005246/1"],"pubmed_authors":["Law ML","Carvalho IB","Carvalho C","Polak ME","Pinto MM","Ardern-Jones M","Bennett CL","Hall NJ","Henderson S","Gentek R","Appios A","Emmerson E","Liu Z","Ginhoux F","Trzebanski S","Lovlekar S","Major C","Sirvent S","Schroth J","Henson SM","Davies J","Vallejo A","Kan HY","Jung S"],"additional_accession":[]},"is_claimable":false,"name":"Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity.","description":"Langerhans cells (LCs) are distinct among phagocytes, functioning both as embryo-derived, tissue-resident macrophages in skin innervation and repair and as migrating professional antigen-presenting cells, a function classically assigned to dendritic cells (DCs). Here, we demonstrate that both intrinsic and extrinsic factors imprint this dual identity. Using ablation of embryo-derived LCs in the murine adult skin and tracking differentiation of incoming monocyte-derived replacements, we found intrinsic intraepidermal heterogeneity. We observed that ontogenically distinct monocytes give rise to LCs. Within the epidermis, Jagged-dependent activation of Notch signaling, likely within the hair follicle niche, provided an initial site of LC commitment before metabolic adaptation and survival of monocyte-derived LCs. In the human skin, embryo-derived LCs in newborns retained transcriptional evidence of their macrophage origin, but this was superseded by DC-like immune modules after postnatal expansion. Thus, adaptation to adult skin niches replicates conditioning of LC at birth, permitting repair of the embryo-derived LC network.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T00:08:47.076Z","creation":"2025-04-04T00:08:47.076Z"},"accession":"S-EPMC7616733","cross_references":{"pubmed":["39241057"],"doi":["10.1126/sciimmunol.adp0344"]}}