biostudies-literatureEMPA-KIDNEY Collaborative GroupHealth Data Research UKBritish Heart FoundationNIHR Oxford Biomedical Research CentreMedical Research CouncilBoehringer IngelheimEli Lilly and Company777-787https://www.ebi.ac.uk/biostudies/studies/S-EPMC7616743biostudies-literatureUnknown392(8)<h4>Background</h4>In the EMPA-KIDNEY trial, empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, had positive cardiorenal effects in patients with chronic kidney disease who were at risk for disease progression. Post-trial follow-up was designed to assess how the effects of empagliflozin would evolve after the discontinuation of the trial drug.<h4>Methods</h4>In the active trial, patients with chronic kidney disease were randomly assigned to receive either empagliflozin (10 mg once daily) or matching placebo and were followed for a median of 2 years. All the patients had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m² of body-surface area or an eGFR of at least 45 but less than 90 ml per minute per 1.73 m<suThe New England journal of medicineLong-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease.PMC7616743MC_UU_00017/3Hooi LGardiner PMartins GKavak YOguchi GGhanem AIwakura TIwasa MCaroppo MSadler EGlowski DFuessl LSumi MHanburry AWanner CHosooka THanf CAker SSchulz EKaneko KWhelton PWatanabe MBurnette SWatanabe KUchida TBudoff MRyder MBrewer GNicola LKawai MMcCray KKawai IOremus RMaris JUchida HStoffler DKupper ABagwell BBusch MDamianik KWolfling RYamanouchi YImamine RMcLaughlin SYarlagadda SSteininger SSuckling RRahbari-Oskoui FWhite KHutchinson CCao HEldon HKuwabara NWei WTan CHHSato YYamasaki NKitagawa MTyler AMacleod PMassey DMarx KHitchcock SMiyaji MRoesch CPTotaro FBarot CSato DHosein DSato AYamashita CValletta CBeekes MZhu DLatif FTonks LSato TZhu 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MUozumi KKoizumi MViera RRogers JShivashankar GTholl SEmberson JJoshi SMohd Fauzi NAYamamoto AHiguchi CYamaguchi MFalcone CAdell VIshikawa TMohamad WHWSchettler EKamaruzaman LMcCarroll FNimbkar TNobili GMah DYCampbell ROlufuwa OJeyarajah DAsahara SSchanz MJimenez GHume LZainal Abidin NNHOkada YCleveland BQuiroga KHarvill LCampbell DKitamura SSchneider-Danwitz CPessolano GShimoda HPutz FFlora REjima YKrish PfalseLong-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease.<h4>Background</h4>In the EMPA-KIDNEY trial, empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, had positive cardiorenal effects in patients with chronic kidney disease who were at risk for disease progression. Post-trial follow-up was designed to assess how the effects of empagliflozin would evolve after the discontinuation of the trial drug.<h4>Methods</h4>In the active trial, patients with chronic kidney disease were randomly assigned to receive either empagliflozin (10 mg once daily) or matching placebo and were followed for a median of 2 years. All the patients had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m² of body-surface area or an eGFR of at least 45 but less than 90 ml per minute per 1.73 m<su2025-01-01T00:00:00Z2025 Feb2026-06-02T04:56:25.423Z2025-04-06T01:57:27.484ZS-EPMC76167433945383710.1056/NEJMoa2409183